Disturbance of the microcirculation and generation of reactive oxygen species are crucial in producing acute gastric mucosal lesions (AGML). To understand the protective mechanism against mucosal injury and oxidative stress in the stomach, we investigated sequential expression and localization of a product of lipid peroxidation and a chemical mediator of the oxidative response array, 4-hydroxyn...

background and purpose: nutrition plays a key role in maintaining and promoting health and preventing diseases. in most medical schools, nutrition education is not sufficient and only 26% of college students have proper nutritional education programs. physicians should use their knowledge through education and counseling with patients and healthy people to increase people’s level of health. poo...

It is speculated more that 400 bacterial species reside in the ora1 eavity and the integrity of oral mucosa is maintained in such an environment. Oral mucosal cells such as epithelial cells and fibroblasts express a wide variety of receptors and preduce many immune regulators i, e., cytokines, chemokines, proteases, and chemical mediators and actively participate in host defenses by interacting...

The endoplasmic reticulum (ER) is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the "unfolded protein response" (UPR), which protects cells from ER stress. Cells undergo apoptosis when ER stress exceeds the capacity of the UPR, which has been rev...

It is speculated more that 400 bacterial species reside in the ora1 eavity and the integrity of oral mucosa is maintained in such an environment. Oral mucosal cells such as epithelial cells and fibroblasts express a wide variety of receptors and preduce many immune regulators i, e., cytokines, chemokines, proteases, and chemical mediators and actively participate in host defenses by interacting...

background: nowadays job stress is one of the most important health problems that health and safety professionals are facing with. much of previous studies have focused on interventions such as stress management and, they have ignored the role of psychosocial factors in occurrence of job stress. this study investigated the mediator role of supervisor support on the association between work stre...

Olive leaf extract (OLE) possesses, among other, antioxidative properties, but whether it influences gastroprotection against stress-induced gastric lesions remains unknown. In this study we investigated the protective effect of OLE, a natural antioxidant, on gastric mucosal damage induced by cold restraint stress (CRS) in rats. Three different doses of commercial OLE EFLA((R)) 943 were applied...