نتایج جستجو برای: soluble leptin receptor

تعداد نتایج: 677692  

Journal: :The Journal of clinical endocrinology and metabolism 2002
Francois M H van Dielen Cornelis van 't Veer Wim A Buurman Jan Willem M Greve

To investigate soluble leptin receptor (sLR) in plasma, specific anti-sLR monoclonal antibodies were developed. Western blot analysis and size exclusion fractionation demonstrated sLR in plasma with a molecular mass of approximately 180,000. Next to this, the presence of sLR-leptin complexes in plasma was confirmed. Using the developed monoclonal antibodies, a specific sLR ELISA was developed, ...

Journal: :World journal of gastroenterology 2008
Xiao-Dong Huang Yan Fan Hen Zhang Ping Wang Jing-Ping Yuan Ming-Jie Li Xi-Yan Zhan

AIM To determine the role of leptin system in non-alcoholic fatty liver disease (NAFLD) development by delineating the changes in serum levels of leptin and soluble leptin receptor (sOB-R). METHODS Blood samples were collected from 30 consecutive patients with liver-biopsy-proven NAFLD and 30 patients with cholecystolithiasis (stationary phase) as controls. Serum leptin levels were determined...

فاروقی, صدف , قدسی, مریم , لاریجانی, باقر , لسان, نادر ,

It is estimated that up to 40-70% of obesities is attributable to genetic factors.  Monogenic forms of obesity are uncommon.  We present the first such reported case in Iran. The patient presented with a history of severe hyperphagia, rapid weight gain and recurrent infections.  He was born after a normal pregnancy in a highly consanguineous marriage.  His birth weight had been normal.  At age ...

Journal: :Diabetes Care 2009
Aoife M. Brennan Jessica L. Fargnoli Catherine J. Williams Tricia Li Walter Willett I. Kawachi Lu Qi Frank B. Hu Christos S. Mantzoros

OBJECTIVE Phobic anxiety has been associated with increased risk of cardiovascular disease (CVD), but the underlying mechanisms are poorly understood. We aimed to determine whether associations of phobic anxiety with several known markers of CVD might be contributors. RESEARCH DESIGN AND METHODS We used a 16-point validated index (Crown-Crisp) measured in 1988 to categorize 984 women with typ...

Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. Leptin has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on leptin signaling has not been clearly understood. In the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...

2012
F.D. Zepf I. Sungurtekin F. Glass L. Elstrodt D. Peetz G. Hintereder J. Kratzsch C.S. Biskup F. Poustka L. Wöckel

BACKGROUND Evidence from animal studies suggests that leptin metabolism is associated with zinc (Zn) status. However, research investigating this relationship in adolescents and young adults with anorexia nervosa (AN) is scarce; the present study aims to fill that gap. METHODS Serum concentrations of leptin, the soluble leptin receptor (sOB-R) and the free leptin index (FLI) were obtained in ...

Journal: :Physiological research 2009
P Maruna J Lindner K M Kubzová

Leptin is a hormone that regulates food intake. During inflammatory status, leptin may contribute to the anorexia and cachexia of infection. Pulmonary endarterectomy was used as a model of non-infectious cytokine network hyperstimulation. Leptin and soluble leptin receptor (SLR) were compared with evolution of cortisol and inflammatory cytokines in twenty-two patients with chronic thromboemboli...

2010
Tommy Jönsson Yvonne Granfeldt Charlotte Erlanson-Albertsson Bo Ahrén Staffan Lindeberg

BACKGROUND We found marked improvement of glucose tolerance and lower dietary energy intake in ischemic heart disease (IHD) patients after advice to follow a Paleolithic diet, as compared to a Mediterranean-like diet. We now report findings on subjective ratings of satiety at meals and data on the satiety hormone leptin and the soluble leptin receptor from the same study. METHODS Twenty-nine ...

Journal: :The Turkish journal of pediatrics 2014
Halil İbrahim Aydın Erkan Demirkaya Rahmi Sinan Karadeniz Abdullah Olgun Faruk Alpay

The aim in this study was to determine the factors affecting leptin and soluble leptin receptor (sOB-R) levels in term small for gestational age (SGA) and appropriate for gestational age (AGA) newborns. The study group consisted of SGA (n=20) and AGA (n=20) newborns and their mothers. The leptin and sOB-R levels were tested using the ELISA method. The cord blood leptin concentrations were found...

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