Local heat transfer coefficients and pressure drops during boiling of the dielectric liquid fluorinert FC-77 in parallel microchannels were experimentally investigated in recent work by the authors. Detailed visualizations of the corresponding two-phase flow regimes were performed as a function of a wide range of operational and geometric parameters. A new transition criterion was developed for...

Slug is an E-cadherin repressor and a suppressor of PUMA (p53 upregulated modulator of apoptosis) and it has recently been demonstrated that Slug plays an important role in controlling apoptosis. In this study, we examined whether Slug's ability to silence expression suppresses the growth of cholangiocarcinoma cells and/or sensitizes cholangiocarcinoma cells to chemotherapeutic agents through i...

BACKGROUND Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas of the gastrointestinal tract. We assessed the relevance of Slug in measuring the invasive potential of ESCC cells in vitro and in vivo in immunodeficient mice. METHODS We utilized RNA interference to knockdown Slug gene expression, and effects on survival and invasive carcinoma were evaluated using ...

In this work, the feasibility of flow pattern and oil hold up the prediction for vertical upward oil–water two–phase flow using pressure fluctuation signals was experimentally investigated. Water and diesel fuel were selected as immiscible liquids. Oil hold up was measured by Quick Closing Valve (QCV) technique, and five flow patterns were identified using high-speed photo...

BACKGROUND Slug has been found to promote migration and invasion of many cancer cells, including anaplastic thyroid cancer (ATC). Thus, targeting Slug expression could provide new approaches for the treatment of patients with ATC. MATERIAL AND METHODS Small interfering RNA (siRNA) targeting Slug (Slug siRNA) was used to construct clonal derivatives in the metastatic ATC SW1736 cells. Slug cDNA ...

PURPOSE TGFbeta is a potent candidate for epithelial-mesenchymal transition (EMT) during the development of anterior polar cataracts in the human lens. The Snail superfamily is involved in EMT through the repression of E-cadherin production. This study was conducted to determine whether the Snail gene family is activated in the process of TGFbeta1-induced EMT and how TGFbeta1 regulates the expr...

This work proposes new semi-analytical solutions for the interpretation of cross-borehole slug tests in fractured media. Our model is an extension of a previous work by Barker (1988) and Butler and Zhan (2004). It includes inertial effects at both test and observation wells and a fractional flow dimension in the aquifer. The model has 5 fitting parameters: flow dimension n, hydraulic conductivi...