نتایج جستجو برای: serotonin 5ht2a receptor

تعداد نتایج: 614261  

Journal: :Chemistry and physics of lipids 2007
Md Jafurulla Amitabha Chattopadhyay

The serotonin 1A receptor is an important member of the G-protein coupled receptor family, and is involved in a variety of cognitive, behavioral, and developmental functions. None of the subtypes of G-protein coupled serotonin receptors have yet been purified to homogeneity from natural sources. We report here, for the first time, the solubilization of human serotonin(1A) receptors stably expre...

Journal: :Turk psikiyatri dergisi = Turkish journal of psychiatry 2009
Elvan Ozalp

There is consistent evidence suggesting that genetic factors play an important role in predisposition to suicidal behavior. Family, twin, and adoption studies have demonstrated that there is a genetic dimension to suicide. Although there is some overlap between suicide and mood disorders, even among psychiatric groups with the highest risk, some patients never attempt suicide, indicating the im...

2015
Lukasz Piszczek Agnieszka Piszczek Joanna Kuczmanska Enrica Audero Cornelius T. Gross

Serotonin (5-HT) plays an important role in the modulation of behavior across animal species. The serotonin 1A receptor (Htr1a) is an inhibitory G-protein coupled receptor that is expressed both on serotonin and non-serotonin neurons in mammals. Mice lacking Htr1a show increased anxiety behavior suggesting that its activation by serotonin has an anxiolytic effect. This outcome can be mediated b...

Journal: :iranian journal of psychiatry and behavioral sciences 0
hamidreza ahmadkhaniha tehran psychiatric institute and mental health research center. iran university of medical science afshin tayebi

neuroleptic malignant syndrome (nms) is a rare fatal medical complication that occurs as a result of dopaminergic receptor blockage in the caudate at the termination of the nigrostriatal pathways (1), and may occur at any time following consumption of dopamine antagonists. this disorder also occurs in cases of sudden discontinuation of dopamine agonists and antagonists (2,3). some studies have ...

A Muragundla C Kanwaljit

Diabetic neuropathic pain, an important micro vascular complication in diabetes mellitus, has been recognized as one of the most difficult types of pain to treat. Lack of understanding of etiology involved, inadequate relief, development of tolerance and potential toxicity of classical anti-nociceptive agents warrants the investigation of newer agents to relieve this pain. The aim of the presen...

Flibanserin is a novel antagonist small molecule to treat the hypoactive sexual desire disorder (HSDD) in the premenopausal women. The present article is related to the structural and electronic properties study and docking analysis of the title compound with 5-hydroxytryptamine 2A (5-HT2A) serotonin receptor. To access these aims, the molecular structure of the said compound was optimized usin...

2010
Kwang-Yeon Choi Ho-Kyoung Yoon Yong-Ku Kim

OBJECTIVE The aim of the present study was to examine the association between serotonin-related gene polymorphisms and bipolar disorder in the Korean population. In addition, we sought to explore the relationship between the clinical characteristics of bipolar patients and serotonin-related gene polymorphisms. METHODS Inpatients with bipolar disorder (n=103) and control subjects (n=86) were g...

Journal: :Archives of general psychiatry 2003
Steven G Potkin Anutosh R Saha Mary J Kujawa William H Carson Mirza Ali Elyse Stock Joseph Stringfellow Gary Ingenito Stephen R Marder

BACKGROUND Aripiprazole is a dopamine D2 receptor partial agonist with partial agonist activity at serotonin 5HT1A receptors and antagonist activity at 5HT2A receptors. This multicenter trial examined the efficacy, safety, and tolerability of aripiprazole in patients with acute exacerbation of schizophrenia or schizoaffective disorder. METHODS In this 4-week double-blind study, 404 patients w...

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