PURPOSE Although most neuroscientists and physicians would argue against Cartesian dualism, Descartes's version of the psyche/soma divide, which has been controversial since he proposed it in the seventeenth century, continues to haunt contemporary neurological diagnoses through terms such as functional, organic, and psychogenic. Drawing on my own experiences as a person with medically unexplai...

background: serum prolactin level has been used as an alternative determinant to help differentiate epileptic from non-epileptic seizures. we aimed to analyze the association between serum prolactin concentration and epileptic seizure versus febrile seizure as well as seizure duration, single versus multiple seizure attacks and time lapse between seizure onset and blood sampling.   methods: sev...

When a comatose patient experiences a seizure event, his or her healthcare provider’s main concern is the stabilization of the patient. However, it is important to provide protection to the oral structures to prevent severe damage from reflex grinding, masticating, and gnawing. There are several appliances available for this necessary protection but these are often inaccessible in developing co...

to determine the anticonvulsant activity of the leaf extract of croton zambesicus in mice and rats, and in order to verify the traditional use of the plant in the treatment of epilepsy. the pentyleneterazole (ptz) and the maximal electroshock seizure (mes) models were used for assessing the anticonvulsant effects of the aqueous leaf extract in mice and rats. in the ptz test, the leaf extract (1...

how to cite this article : molla mohammadi m, tonekaboni sh, khatami ar, azargashb e, tavasoli a, javadzadeh m, zamani gr. neuroimaging findings in first unprovoked seizures: a multicentric study in tehran. iran j child neurol. 2013 autumn; 7(4):24-31. objective seizure is an emergency in pediatrics. it really matters to the parents of the involved child to have information about the causes, ma...

Release of prostaglandins in brain after spontaneous and experimentally induced seizures, has been demonstrated. The possible role of prostaglandins in modulation of seizure activity is still inconclusive. In the present study, the effects of aspirin and its interaction with the anticonvulsants (diazepam and sodium valproate) were studied in pentylenetetrazole (PTZ) and maximal electroshock (ME...

Background: There have been some reports about the possible N-methyl-D-aspartate (NMDA) antagonist activity of Guaifenesin. As drugs with a similar structure to Guaifenesin (i.e. Felbamate) and those with NMDA antagonist activity have been clinically used as anticonvulsants, the aim of this study was to determine whether Guaifenesin has an anticonvulsant effect in an animal model of seizure. ...

Seizures remain uncontrolled in 30% of patients with epilepsy, even with concurrent use of multiple drugs, and uncontrolled seizures result in increased morbidity and mortality. An extreme example is Dravet syndrome (DS), an infantile-onset severe epilepsy caused by heterozygous loss of function mutations in SCN1A, the gene encoding the brain type-I voltage-gated sodium channel NaV1.1. Studies ...

In newborn pigs, the mechanism of seizure-induced cerebral hyperemia involves carbon monoxide (CO), the vasodilator product of heme catabolism by heme oxygenase (HO). We hypothesized that seizures cause cerebral vascular dysfunction when HO activity is inhibited. With the use of cranial window techniques, we examined cerebral vascular responses to endothelium-dependent (hypercapnia and bradykin...

Introduction: The life quality of patients with epileptic seizures is highly affected by cognitive deficits. Low Frequency Stimulation (LFS) is a novel approach for the treatment of pharmacoresistant epilepsy. The main goal of this research is investigating the possible effect of LFS on seizure-induced cognitive dysfunction.  Methods: To this end, the kindled animal were prepared via CA1 ...