As a natural flavonoid compound, rutin could scavenge free radicals effectively to achieve remarkable antioxidant and anti-photoaging activity. Unfortunately, the extremely low water solubility of often leads poor percutaneous permeability unsatisfactory bioavailability, which has greatly restricted its clinical application. In this study, novel freeze-dried nanocrystal was developed improve sa...

iii Abstract Solubility Modelling in Condensed Matter. Dielectric Continuum Theory and Nonlinear Response. Lars Sandberg, Theoretical Biophysics Group, Department of Physics, Royal Institute of Technology, SE-106 91 Stockholm, SWEDEN.Solubility Modelling in Condensed Matter. Dielectric Continuum Theory and Nonlinear Response. Lars Sandberg, Theoretical Biophysics Group, Department of Physics, R...

Urinary stone disease is global problem and is due to alteration in the normal crystallization environment of urine in the urinary tract systems. Major factors responsible for crystal formation are super-saturation of Ca salts and level of crystallization inhibitors (Citrate & Phytate). Excessive citrate intake makes the urine more alkaline (pH between 6 and 7). This can be achieved by oral adm...

Aquatic ectotherms face the continuous challenge of capturing sufficient oxygen from their environment as the diffusion rate of oxygen in water is 3 x 10(5) times lower than in air. Despite the recognized importance of oxygen in shaping aquatic communities, consensus on what drives environmental oxygen availability is lacking. Physiologists emphasize oxygen partial pressure, while ecologists em...

BACKGROUND The quality of the coronal seal of root canal filling material is important for periapical health. Absorption of water or saliva by the temporary restorative materials leads to dimensional changes, loss of retention, staining and breaking in margin contours. Hence this study was carried out to evaluate and compare the sealing properties, water absorption and solubility of IRM (interm...

The prediction of the solubility active pharmaceutical ingredients (APIs) is a significant challenge which importance in applications and solvent selection. Here, we extend table group interactions (3 like interactions, 47 unlike interactions) SAFT-γ Mie group-contribution equation state to model phase behaviour mefenamic acid, nonsteroidal anti-inflammatory drug, range solvents. In addition al...

We have established that 2,3-diphosphoglycerate (2,3-DPG) content and intracellular pH exert separate, but interdependent, effects on the equilibrium solubility (csat) of deoxyhemoglobin S (deoxy-Hb S) that act in concert to modulate intraerythrocytic polymer formation. In a nonphysiologic csat assay system, a steep dependence of csat on pH in the physiologic range 7.0 to 7.6 was shown for both...

in this study, the ion association phenomenon in the saturated solution of kcl in the mixed solvent(methanol+water) was studied. the solubility of this compound in the mixed solvent (methanol+water by value percent of methanol = 60%), and in the presence of various molarities of nano3 wasdetermined by the solvent evaporation method at 25.0°c. the results enable us to estimate the valueof thermo...

With the limitation of solubility and dissolution rate insoluble drugs, following oral administration, they would rifely prove poor volatile bioavailability, which may fail to realize its therapeutic value. The drug nanocrystals are perceived as effective tactic for administration drugs attributes possess many prominent properties such elevating saturation solubility, high loading capacity, imp...

We introduce a composite tracer for the marine system, Alk, that has a global distribution primarily determined by CaCO3 precipitation and dissolution. Alk ∗ is also affected by riverine alkalinity from dissolved terrestrial carbonate minerals. We estimate that the Arctic receives approximately twice the riverine alkalinity per unit area as the Atlantic, and 8 times that of the other oceans. Ri...