0308-8146/$ see front matter 2011 Elsevier Ltd. A doi:10.1016/j.foodchem.2011.09.125 ⇑ Corresponding author. Tel.: +32 2764 7234; fax: + E-mail address: [email protected] ( 1 F.R.S.-FNRS Post-Doctoral Researcher (Belgium). This study describes the development of a validated method for the quantification of rotenone in yam bean. The milled seeds were submitted to a Soxhlet dichlorom...

BACKGROUND Mitochondrial dysfunction and oxidative stress are the main toxic events leading to dopaminergic neuronal death in Parkinson's disease (PD) and identified as vital objective for therapeutic intercession. This study investigated the neuro-protective effects of the demethoxycurcumin (DMC), a derivative of curcumin against rotenone induced neurotoxicity. METHODS SH-SY5Y neuroblastoma ...

Nutraceuticals play an essential role in the reduction free radical generation cells. A similar idea was used present study to determine effects of aqueous extracts on organismal toxicities a nontarget organism, Drosophila melanogaster, known as fruit fly. Punica granatum (peel and pulp), Carica papaya (peel), Foeniculum vulgare (seeds), Trigonella foenum-graecum Urtica dioica (leaves) were emp...

Acetate-lJ*C incorporation into long chain fatty acids by rabbit heart mitochondria was increased up to ZO-fold by citrate, isocitrate, malate, or succinate in the presence of rotenone and ATP. Rotenone blocked NADH oxidation and enabled the maintenance of a high NADH:NAD+ ratio. The rate of fatty acid synthesis was linearly related to the resulting endogenous mitochondrial NADH : NAD+ ratio. B...

It has been confirmed that mitochondrial impairment may underlie both sporadic and familial Parkinson's disease (PD). Mitochondrial fission/fusion and biogenesis are key processes in regulating mitochondrial homeostasis. Therefore, we explored whether the protective effect of resveratrol in rotenone-induced neurotoxicity was associated with mitochondrial fission/fusion and biogenesis. The resul...

Neoechinulin A, an indole alkaloid from marine fungi, can protect PC12 cells from the cytotoxicity of 1-methyl-4-phenylpyridinium (MPP(+)), a Parkinson disease-inducing neurotoxin, by ameliorating downstream events resulting from mitochondrial complex I inactivation. However, the cytoprotective mechanisms remained unclear. In this study, by using rotenone, another parkinsonian-inducing neurotox...

Rotenone, an inhibitor of mitochondrial complex I of the mitochondrial respiratory chain, is known to elevate mitochondrial reactive oxygen species and induce apoptosis via activation of the caspase-3 pathway. Bee venom (BV) extracted from honey bees has been widely used in oriental medicine and contains melittin, apamin, adolapin, mast cell-degranulating peptide, and phospholipase A₂. In this ...

The effects of rotenone on the succinate-driven reduction of matrix nicotinamide nucleotides were investigated in Percoll-purified mitochondria from potato (Solanum tuberosum) tubers. Depending on the presence of ADP or ATP, rotenone caused an increase or a decrease in the level of reduction of the matrix nicotinamide nucleotides. The increase in the reduction induced by rotenone in the presenc...

Obstructive kidney disease is a common complication in the clinic. Downregulation of aquaporins (AQPs) in obstructed kidneys has been thought as a key factor leading to the polyuria and impairment of urine-concentrating capability after the release of kidney obstruction. The present study was to investigate the role of mitochondrial complex-1 in modulating AQPs in obstructive nephropathy. Follo...

Parkinson disease (PD) is characterized by selective loss of the dopaminergic neurons. The symptoms of depression following PD are closely associated with reduced activity of the serotonergic system in the dorsal raphe. We explored the antidepressive effect of exercise and its possible mechanism using the rotenone-induced PD rats. PD rats were induced by subcutaneously injection with rotenone f...