In this issue of Molecular Cell, Di Giammartino et al. (2012) identify a new function for PARP1 in the post-transcriptional regulation of mRNAs via ADP-ribosylation of poly(A) polymerase, a mRNA 3′ processing enzyme. Poly(ADP-ribose) polymerase 1 (PARP1, also known as ARTD1) is an abundant nuclear protein that covalently modifies target proteins with poly(ADP-ribose) (PAR) using NAD+ as a subst...

Cryogenics is the continuation of heat treatment and is the last step that completes the thermal treatment processing of metals. After ferrous steel part/s are heat-treated and tempered, the part’s grain structure can be improved by subjecting the part to a deep cryogenic temperature (–320 °F) soak. The process involves taking the parts down from room temperature to –70 °F to –100 °F using dry ...

We experimentally produced an easily debondable orthodontic adhesive (EDA) containing heat-expandable microcapsules. The purpose of this in vitro study was to evaluate the best debondable condition when EDA was used for ceramic brackets. Shear bond strengths were measured before and after heating and were compared statistically. Temperatures of the bracket base and pulp wall were also examined ...

in this investigation, fluor-hydroxyapatite (fha) film was deposited on a titanium substrate by sol-gel method. triethyl phosphite, ammonium fluoride and calcium nitrate in ethanol solutions were used respectively as p, f and ca precursors. typical apatite structures were obtained for all coatings after dipping and subsequent heat treatment at 550, 700 and 800 ºc, the coating layers were invest...

The hormone oxytocin has been hypothesized to influence the emotional dimension of pain. This randomized, placebo-controlled, double-blind, crossover study explored whether intranasal oxytocin and emotional context can affect heat pain perception in 30 healthy male volunteers. After receiving 36 IU oxytocin or placebo, participants underwent functional Magnetic Resonance Imaging (fMRI) during w...

Although road traffic has supported high economic growth after the war, it has also caused serious social problems about traffic accidents, traffic congestion, and environmental pollution. Information and communication technology (ICT), such as computers, mobile communications, and digital information processing, has made rapid progress, in the second half of the 20th century. Intelligent Trans...

Herein, we investigated the effects of passive heat stress on human somatosensory processing recorded by somatosensory-evoked potentials (SEPs). Fifteen healthy subjects received a median nerve stimulation at the left wrist under two thermal conditions: Heat Stress and normothermic Time Control. The latencies and amplitudes of P14, N20, P25, N35, P45, and N60 at C4' and P14, N18, P22, and N30 a...

Heat resistance at 95 C, heat activation at 75 C, and germination response were determined for spores of 10 serotype strains of Clostridium perfringens type A, including five heat-resistant and five heat-sensitive strains. The D95-values ranged from 17.6 to 63.0 and from 1.3 to 2.8 for the heat-resistant and the heat-sensitive strains, respectively. The heat-activation values, the ratios betwee...

  SUMMARY Since at oocyte retrieval for in vitro fertilization there is some FF become incorporate to egg, we decided to investigate the effect of this fluid on preimplantation embryo development in vitro. FF was obtained at the time of oocyte retrieval for IVF, centrifuged and then either inactivated by heat and stored at 4°c or without inactivation stored at-20°c until used. Late 2-cell emb...