Aldosterone blockade confers substantial cardiovascular and renal protection. The effects of aldosterone on mineralocorticoid receptors (MR) expressed in endothelial cells (EC) within the renal vasculature have not been delineated. We hypothesized that lack of MR in EC may be protective in renal vasculature and examined this by ablating the Nr3c2 gene in endothelial cells (EC-MR) in mice. Blood...

Protection against puromycin aminonucleoside (PAN) induced chronic renal disease in the Wistar Furth rat. Abstract: The Wistar Furth (WF) rat is protected against chronic renal disease (CRD) following 5/6 th ablation/infarction (A/I) vs the Sprague Dawley (SD) and protection was associated with preserved renal NO production. This study examined CRD induced with repeated administration of puromy...

The benefits and risks of steroids for the treatment of IgA nephropathy remain uncertain. We systematically searched MEDLINE, EMBASE, and the Cochrane Library for randomized, controlled trials of corticosteroid therapy for IgA nephropathy published between 1966 and March 2011. We identified nine relevant trials that included 536 patients who had urinary protein excretion >1 g/d and normal renal...

fusion, leading to reduced phosphorylation of MAPKs. It is possible that the reduction in ERK and JNK phosphorylation is an epi-phenomenon, and not the mechanism of isoflurane protection. Finally, Hashiguchi et al. describe two renal ischemia protocols: bilateral renal ischemia for plasma creatinine measurement and histology, and unilateral renal ischemia for immunoblotting studies. Bilateral a...

Renal ischemic reperfusion (IR) injury is a significant clinical problem in anesthesia and surgery. Recently, it was demonstrated that both renal ischemic preconditioning (IPC) and systemic adenosine pretreatment protect against renal IR injury. In cardiac IPC, pertussis toxin-sensitive G-proteins (i.e., G(i/o)), protein kinase C (PKC), and ATP-sensitive potassium (K+(ATP)) channels are implica...

This study reports the presence of a retro-aortic renal vein on the left side draining into the inferior vena cava. This variation was observed during routine dissection in a female cadaver aged about 55 years. This variation is of importance because of its implications in renal transplantation, renal surgery, vascular surgery, uroradiology and gonadal surgeries. The knowledge of such variation...

fusion, leading to reduced phosphorylation of MAPKs. It is possible that the reduction in ERK and JNK phosphorylation is an epi-phenomenon, and not the mechanism of isoflurane protection. Finally, Hashiguchi et al. describe two renal ischemia protocols: bilateral renal ischemia for plasma creatinine measurement and histology, and unilateral renal ischemia for immunoblotting studies. Bilateral a...

The purpose of this study was to investigate whether local mechanisms of blood flow autoregulation mediate vasoconstriction during the early development of renal hypertension. Anesthetized rats were instrumented with Doppler flow probes on the celiac (CA), superior mesenteric (SMA), and renal arteries to measure flow velocity in these vessels. Acute two-kidney, one clip renal hypertension was p...