Abstract Study question To identify the mechanism of Inhibin Subunit Beta B (INHBB) in regulation human endometrial stromal cells (HESCs) decidualization recurrent implantation failure (RIF). Summary answer INHBB was decreased women with RIF, which attenuated vitro by suppressing ADCY1-induced cAMP production and cAMP-mediated signalling. What is known already encodes a preprotein subunit inhib...

OBJECTIVE The purpose of this study was to evaluate the efficacy of frozen mixed double-embryo transfer (MDET; the simultaneous transfer of day 3 and day 5 embryos) in comparison with frozen blastocyst double-embryo transfer (BDET; transfer of two day 5 blastocysts) in patients with repeated implantation failure (RIF). METHODS A total of 104 women with RIF who underwent frozen MDET (n=48) or ...

This study aims to investigate whether personalized embryo transfer (pET) guided by endometrial receptivity analysis (ERA) improves the clinical pregnancy rate for non-recurrent implantation failure (non-RIF) in vitro fertilization (IVF) patients Chinese population. is a single-center, retrospective cohort of with 0-2 previous failed implantations following high-quality at Chengdu Jinjiang Dist...

background: despite major advances in assisted reproductive techniques, the implantation rates remain relatively low. some studies have demonstrated that intrauterine infusion of granulocyte colony stimulating factor (g-csf) improves implantation in infertile women. objective: to assess the g-csf effects on ivf outcomes in women with normal endometrial thickness. materials and methods : in this...

PROBLEM Increasing evidence suggests modulation of the maternal immune response to be essential for successful pregnancy. We studied the immunophenotypic profile and function of peripheral blood T lymphocytes in infertile women undergoing in vitro fertilization (IVF) and fertile control population. METHOD We collected peripheral blood mononuclear cells (PBMC) from infertile patients with recu...

background: recently, the use of granulocyte colony-stimulating factor (g-csf) has been proposed to improve pregnancy outcomes in reproductive medicine. objective: a systematic review of the current use of g-csf in patients who have difficulty conceiving and maintaining pregnancy was performed. materials and methods: two electronic databases (pubmed/ medline and scopus) were searched. study sel...

Abstract Study question In couples with Recurrent Implantation Failure (RIF), can Pre-implantation Genetic Testing for Aneuploidy (PGT-A) or Endometrial Receptive Array (ERA) help to optimise the reproductive outcomes? Summary answer RIF patients PGT-A ERA individually do not seem optimize outcomes. in-combination seems be a beneficial intervention. What is known already Role of and outcomes ha...