In this study we investigated the pharmacology of lobeline, a high affinity nicotinic ligand with a unique pharmacological profile, in different in vitro and in vivo tests. Although lobeline displaced [3H]-nicotine binding sites in the rat brain with a Ki of 4.4 nM, it did not activate alpha4beta2 expressed receptors in frog oocytes. The in vivo pharmacological effects of lobeline were highly c...

Objective: Acute liver injury (ALI) has become a major reason for emergency transplantation mortality worldwide. Diwuyanggan (DWYG), hospital preparation of traditional chinese medicine, does satisfactory job treating disease, but its pharmacological mechanisms should be further investigated. Thus, we aimed to unravel the DWYG against ALI through comprehensive approach integrating metabolomics ...

Cannabis sativa L. (cannabis) is a medicinal plant and has been used for many years the treatment of epilepsy (EP), which common neurological disease. This study aimed to investigate mechanism cannabis action in EP, with emphasis on leading compounds, targets pathways. In this study, systematic pharmacology bioinformatics approaches were employed identify active ingredients potential treating E...

There are no known drugs or drug combinations that promote substantial central nervous system axonal regeneration after injury. We used systems pharmacology approaches to model pathways underlying growth and identify a four-drug combination regulates multiple subcellular processes in the cell body axons using optic nerve crush rats. intravitreally injected agonists HU-210 (cannabinoid receptor-...

This Commentary focuses on two articles in the October 2015 issue of Molecular Pharmacology that investigate the role of m-opioid receptor phosphorylation in receptor agonist binding and desensitization. The work of Birdsong et al. and Yousuf et al. clearly highlights the complexity that researchers face when trying to assess the signaling and regulatory consequences of G protein–coupled recept...