Exposure to naturally occurring and man-made radionuclides can occur through drinking water or via inhalation or dermal pathways while showering or during other contact with the water. R adioactivity surrounds us; each day we are exposed to a certain amount by virtue of being alive on planet Earth. Some of this exposure comes from radioactive substances (radionuclides) that occur naturally in a...

Monoclonal antibodies (mAbs) have long been recognized as effective tumor-targeting vehicles. Targeted delivery of radionuclides to tumorassociated antigens for imaging and therapy of cancer is an active research area in the preclinical as well as the clinical domain [2]. The U.S. Food and Drug Administration’s (FDA) approval at the beginning of this century of the first two radiolabeled monocl...

background: the natural radionuclides are always present in soil and care needs to be taken to minimize the radiation dose to humans. these radionuclides are mostly gamma ray emitting radionuclides which contribute to the radiation dose in long term behavior of radionuclides in soil. health hazards associated with natural radioactivity are of great concern and it is necessary to assess risk due...

introduction:the use of beta emitters is one of the effective methods for palliation of bone metastasis. the risk of normal tissue toxicity should be evaluated in the bone pain palliation treatment. methods: in this study, the monte carlo simulation code mcnpx was used for simulation a bone phantom model consisted of bone marrow, bone and soft tissue. specific absorbed fractions were calculated...

PURPOSE The most commonly used technology currently used for autoradiography is storage phosphor screens, which has many benefits such as a large field of view but lacks particle-counting detection of the time and energy of each detected radionuclide decay. A number of alternative designs, using either solid state or scintillator detectors, have been developed to address these issues. The aim o...

Brain metastases develop frequently in patients with breast cancer, and present a pressing therapeutic challenge. Expression of vascular cell adhesion molecule 1 (VCAM-1) is upregulated on brain endothelial cells during the early stages of metastasis and provides a target for the detection and treatment of early brain metastases. The aim of this study was to use a model of early brain metastasi...

From the Newsline editor: Across the globe, the practice of nuclear medicine depends on the sometimes difficult-toachieve confluence of skilled practitioners, specialized equipment, and readily available supplies of short-lived radionuclides. As a result of variations in each of these crucial elements, the practice of nuclear medicine can be quite different from one region of the world to anoth...

Click chemistry has become a ubiquitous chemical tool with applications in nearly all areas of modern chemistry, including drug discovery, bioconjugation, and nanoscience. Radiochemistry is no exception, as the canonical Cu(I)-catalyzed azide-alkyne cycloaddition, strain-promoted azide-alkyne cycloaddition, inverse electron demand Diels-Alder reaction, and other types of bioorthogonal click lig...

Methods Starting point of the analysis is the Linear Non Threshold (LNT) assumption for radiation stochastic effect [1]: for effective doses (E) below 100 mSv, the probability of future stochastic damage is linearly related to E. This allows to add E from different sources to calculate a cumulative risk of health detriment. Data coming from literature were gathered to determine the average E de...