Therapy for non-Hodgkin's lymphoma has progressed significantly over the last decades. However, the majority of patients remain incurable, and novel therapies are needed. Because immunotherapy ideally offers target selectivity, an ever increasing number of immunotherapies, both passive and active, are undergoing development. The champion of passive immunotherapy to date is the anti-CD20 monoclo...

Pancreatic Ductal Adenocarcinoma (PDA) is an almost incurable radio- and chemo-resistant tumor, and its microenvironment is characterized by a strong desmoplastic reaction associated with a significant infiltration of T regulatory lymphocytes and myeloid-derived suppressor cells (Tregs, MDSC). Investigating immunological targets has identified a number of metabolic and cytoskeletal related mole...

Epidemiologic, clinical, morphologic and molecular evidence show that high risk HPV, particularly type 16, is a prerequisite for some carcinomas of the upper aerodigestive tract (UADT), particularly tonsil and base of tongue. Sexual transmission is an important mode of infection while tobacco use and excessive drinking are not considered risk factors. HPV + tumors are distinct clinically and pa...

This study presents a full-duplex Radio-over-Fiber (RoF) system providing the users' wireless access with a bit rate of 10 Gbps over 40 GHz radio carrier. This system can be used in a centralized radio access network (C-RAN) architecture because we provide a fully analog front haul link between central station and base station. We can consider it as infrastructure between remote radio heads (RR...

Background: Recent studies indicate an increased incidence of pertussis disease in recent years. The aim of this study was to evaluate the efficacy of the acellular vaccine for children (as a replacement of current whole cell vaccine in the Expanded Program on Immunization) and for high-risk adults in Iran through updating current best available evidence.   Methods: We performed a syste...

multicast routing is one of the most important services in multi radio multi channel (mrmc) wireless mesh networks (wmn). multicast routing performance in wmns could be improved by choosing the best routes and the routes that have minimum interference to reach multicast receivers. in this paper we want to address the multicast routing problem for a given channel assignment in wmns. the channels...

many appealing multicast services such as on-demand tv, teleconference, online games and etc. can benefit from high available bandwidth in multi-radio multi-channel wireless mesh networks. when multiple simultaneous transmissions use a similar channel to transmit data packets, network performance degrades to a large extant. designing a good multicast tree to route data packets could enhance the...

in this study, five carp pituitary glands were collected and dispersed enzymatically and mechanically.then, the cells were cultivated as monolayer in mem (minimum essential medium eagle). the culture mediawere collected after 72 h and frozen at -20°c. carp ovarian follicles also were separated mechanically andincubated in bss (basic salt solution) cortland medium in 24-well microplates for 48 h...

OBJECTIVES After a cluster of rapidly fulminant influenza related toddler deaths in a Western Australian metropolis, children aged six to 59 months were offered influenza vaccination in subsequent winters. Some parental resistance was expected and previous poor uptake of paediatric influenza vaccination overseas was noted. A marketing campaign addressing barriers to immunization was developed t...