Background—Increased QTc dispersion has been associated with an increased risk for ventricular arrhythmias and cardiac death in selected patient populations. We examined the association between computerized QTc-dispersion measurements and mortality in a prospective analysis of the population-based Rotterdam Study among men and women aged $55 years. Methods and Results—QTc dispersion was compute...

BACKGROUND Acute exposure to ambient air pollution has been associated with acute changes in cardiac outcomes, often within hours of exposure. OBJECTIVES We examined the effects of air pollutants on heart-rate-corrected QT interval (QTc), an electrocardiographic marker of ventricular repolarization, and whether these associations were modified by participant characteristics and genetic polymo...

BACKGROUND At dosages above 0.1 mg/kg, droperidol induces a dose-dependent QTc interval prolongation. Although subject to controversy, low-dose droperidol has recently been suspected to induce cardiac arrhythmias. Hence, 5-hydroxytryptamine type 3 antagonists have become the first-line drug for management of postoperative nausea and vomiting. These drugs are also known to prolong the QTc interv...

BACKGROUND This study evaluated the effects of atypical antipsychotic drugs and selective serotonin reuptake inhibitors (SSRIs) on the corrected QT (QTc) interval using a large database obtained from clinical settings. Additionally, the effects of factors including age on QTc intervals were estimated. METHODS Using an open-access QT database (ECG-ViEW), QTc-lengthening effects of 14 selected ...

PURPOSE A QT interval correction to standardized heart rate (QTc) is essential to compare drug effect or to mitigate cardiac risk in clinical practice. Numerous empirical formulas for QTc have been proposed. However, an effective and readily comprehensible method has been elusive. As QTc is dependent on demographics, concomitant drugs, health status, autonomic and diurnal variation, the applica...

Objective The main purpose of the current study was to investigate the association between QTc and various insulin sensitive or insulin resistant adipocytokines such as leptin, adiponectin, RBP4, and PAI-1 as well as inflammatory markers, oxidative stress and endothelial function in patients with type 2 diabetes. Method QTc, blood and urine tests were performed in 101 type 2 diabetic patients h...

QTc interval prolongation is a side effect of several antipsychotic drugs, with associated risks of torsade de pointes arrhythmias and sudden cardiac death. There is an ongoing debate of whether or not electrocardiogram (ECG) assessments should be mandatory in patients starting antipsychotic drugs. To investigate QTc prolongation in a clinically relevant patient group 171 adult patients acutely...

Background: We designed a cross-sectional study to determine electrocardiographic disorders in Down syndrome patients with congenitally normal hearts in a bid to predict fatal cardiac arrhythmia in the future. Materials and Methods: We investigated 60 children with DS without congenital abnormal hearts. Sixty healthy juveniles were also included in the study as a control group. Physical examina...

Cardiac arrest due to torsades de pointes (TdP) is an uncommon but potentially catastrophic event associated with QT interval-prolonging drugs [1]. Numerous medications that may cause TdP are available for use in clinical practice, and include drugs for management of cardiovascular diseases, primarily arrhythmias, but also noncardiovascular agents from multiple classes, including antiinfectives...