It is shown that owing to a dominance of np−pair transfer mechanism of backward elastic p Hescattering for incident proton kinetic energies Tp > 1 GeV the cross section of this process is defined mainly by the values of the Faddeev component of the wave function of He nucleus, φ(q23,p1), at high relative momenta q23 > 0.6GeV/c of the NN-pair in the S0− state and at low spectator momenta p1 ∼ 0−...

Introduction. Myelodysplastic/myeloproliferative neoplasms represent a group of rare hematologic malignancies with concomitant characteristics two different disorders. There are cytopenias and cytoses dysplastic morphology in the circulating blood hyperplastic bone marrow, respectively. Many cytogenetic molecular features have been found this entity, but t(2;11)(p21;q23)del(5) (q22;q33) has not...

The translocation t(9;11)(p22;q23) generates the MLL-AF9 oncogene and is commonly associated with monocytic acute myeloid leukemia (AML-M5; FAB-classification). For the oncogenicity of MLL-AF9, the (over)expression of several other genes, including selected HOXA cluster genes as well as MEIS1 (a HOX cofactor), is required. We previously showed that the down-regulation of MLL-AF9 expression is n...

Amplification of chromosomal DNA is thought to be one of the mechanisms that activate cancer-related genes in tumors. In a recent study, we identified high copy-number amplification at 11q21-q23 in cell lines derived from esophageal squamous cell carcinomas (ESCs) using comparative genomic hybridization. Because 11q21-q23 amplification has been reported in tumors of various other types as well,...

BACKGROUND AND OBJECTIVES MLL translocations generate a fusion gene between the 5' end of MLL and the 3' end of different partner genes. Several chromosomal mechanisms including complex and cryptic changes lead to these recombinations. Our objective was to analyze the molecular composition of chromosomes in complex karyotypes with specific MLL translocations. DESIGN AND METHODS Fluorescence i...

To the Editor: Omphalocele is not an uncommon malformation; however, it usually occurs sporadically with less than a 1% recurrence risk (Winter & Baraitser 1991 ). We present recurrence of omphalocele in siblings with partial trisomy 3q and partial monosomy 1 lq as the unbalanced product of a t (3; 1 1 ) (q21;q23)mat. This was the fourth pregnancy of an unrelated couple. The mother had one heal...

We previously demonstrated that the 11q23 breakpoint region, des ignated the RCK locus, of the RC-K8 B-lymphoma cell line with t(l 1;14@q23;q32)is centromeric to PBGD, while breakpoints of infan tile leukemia cell lines with t(l1;19Xq23;p13) are detectable by pulsed field gel electrophoresis with the CD3D probe. In the present study, using a probe within 1.0 kilobase ofthe t(11;14) breakpoint, ...

Metastasis suppressor activities have previously been mapped to human chromosomes 17 and 11. Decreased expression of the metastasis suppressor gene NM23, which is located on chromosome 17, has been correlated with increased metastatic potential in mammary cancers. A region on human chromosome 11, from 11p11.2-p13, has been shown to suppress metastasis in rat prostatic carcinoma cells. In both c...

The t(11;17) has been described in patients with acute myeloid leukemia (AML), and the AF17 gene was previously cloned as a fusion partner of the MLL gene in t(11;17)(q23;q21)-AML. We analyzed one patient with de novo AML and one with therapy-related AML with t(11;17)(q23;q25) and identified the AF17q25 gene on chromosome 17q25, a putative septin family gene, fused with MLL. AF17q25 encoded at ...

About 5% of adult B-cell acute lymphoblastic leukemias (B-ALL) are characterized by t(4;11)(q21;q23), which confers peculiar features to this B-ALL subtype, including a very immature immunophenotype and poor prognosis. We describe the case of a 21-year-old female who presented with B-ALL carrying the t(4;11)(q21;q23) and blasts positive for CD19, TdT, CD79a, CD38, HLA-DR. Before completing the ...