The etiology of purpura in Sjögren syndrome (SS) includes cryoglobulinemia, hypergammaglobulinemia, and leukocytoclastic vasculitis (LCV). The clinical symptoms of LCV associated with SS comprise palpable or nonpalpable purpura and urticarial vasculitis. Here, we report a case of LCV presenting as erythema gyratum repens (EGR)-like purpura in a 62-year-old woman with rheumatoid arthritis and SS...

Immune thrombocytopenic purpura is an acquired autoimmune disorder that is the most common cause of thrombocytopenia in children. The endocannabinoid system is involved in immune regulation. We evaluated a common missense variant (CAA/CGG; Q63R) of the gene encoding the cannabinoid receptor type 2 (GeneID 1269) in 190 children with immune thrombocytopenic purpura and 600 healthy controls. The a...

We report a rare association of Henoch-Schönlein Purpura with recurrent endocarditis in a 36-year-old man presenting with rash and renal failure. Bacterial endocarditis can be complicated by renal failure of various etiologies. Biopsy may distinguish these and guide therapy as seen in this case. Here, timely diagnosis of Henoch-Schönlein Purpura in the setting of recurrent methacillin sensitive...

BACKGROUND Schönlein-Henoch purpura is a systemic vasculitis that affects vessels of a small caliber and rarely reported in the literature. CASE PRESENTATION We report on a 35-year-old woman who developed palpable purpura with necrotizing cutaneous lesions on the lower limbs at 27 weeks of gestation. She also complained of epigastric pain and arthralgias. Histologic examination of a skin biop...

In spite of the universal use of sulphonamides there have apparently been reports of the occurrence of purpura following their administration on only twenty-two occasions. In fourteen cases the thrombocytes were found to be reduced in number, absent from blood films or below 100,000 per c.mm.; in four cases the thrombocyte count exceeded 125,000 per c.mm. and in four the count was not recorded....

We report a 16-year-old previously healthy boy who was admitted to hospital with fever, constitutional symptoms, purpura, additive arthritis, dysentery, rapid progressive renal failure, resembling Henoch- Schuenlein purpura, accompanied with retropharyngeal abscess. Kidney biopsy revealed rapid progressive glomerulonephritis with crescent formation, without immune deposition in immune fluoresce...

A 70-year-old man with acute pancreatitis (acute exacerbation of chronic pancreatitis) was admitted to our department. Despite temporary improvement, the pancreatitis worsened on the 21st hospital day, forming a pancreatic pseudocyst, with infection in the cyst. After treatment with various antibiotics, a blood test on the 71st hospital day indicated improved inflammatory response despite conti...

Non-traumatic stereotyped postictal purpura is rare. A 25-year-old woman presented with right facial, cheek and periorbital purpuric eruptions that occurred after secondarily generalized tonic-clonic seizures. The stereotyped, invariably right-sided facial skin eruption, which resolved in 48 hours, falsely raised concerns of spousal abuse. Possible pathophysiological mechanisms include: (a) val...

A 54-year-old Japanese man noticed painful swelling and redness of his left leg. He was admitted for treatment of cellulitis, which was accompanied with increased anti-streptolysin O and anti-streptokinase titers in his clinical course. After Piperacillin/Tazobactam administration, the skin lesion resolved. However, the patient then developed arthritis, palpable purpura, and intermittent abdomi...

Q1: How would you describe these skin lesions? What is the differential diagnoses? Figure 1 (see p 430) shows confluent ecchymosis in the background of icteric skin, mainly involving the left thigh. The differential diagnoses of non-palpable purpura/ ecchymosis include primary skin conditions (trauma, solar purpura, steroid purpura, capillaritis, and lividoid vasculitis), clotting disorders (th...