A major impact of global climate change has been the marked increase worldwide in the incidence of coastal hypoxia (dissolved oxygen, DO<2.0 mg l-1). However, the extent of hypoxia exposure to motile animals such as fish collected from hypoxic waters as well as their molecular and physiological responses to environmental hypoxia exposure are largely unknown. A suite of potential hypoxia exposur...

The effect of five different mixtures containing xanthan gum (XG), maltodextrin (MD) and arabic (GA) on microencapsulation by spray drying mixed acerola ciriguela juice was investigated in order to preserve its contents ascorbic acid (AA), total phenolic compounds (PC) carotenoids (TC), as well antioxidant activity (AO) under temperatures. All microcapsules produced with the showed effective AA...

This study aimed to assess the main factors affecting goat milk yield and composition from Northwest region of Tunisia. A survey a sampling campaign were conducted over four months (February-May, 2018), within 112 farms in 3 regions. Individual daily (DMY) was registered samples taken duplicate be analysed for fat (FC), protein (PC), solid not (SNF), density lactose contents. Results showed tha...

Mesangial proliferative glomerulonephritis (MsPGN) is characterized by widespread mesangial cell proliferation and an accumulation of extracellular matrix (ECM) in the mesangial area. In a previous study we developed a polycystin‑1 N‑terminal fragment (PC‑1 NF) fusion protein that inhibits the proliferation of cyst‑lining epithelial cells in autosomal dominant polycystic kidney disease. In addi...

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AIMS The receptor for advanced glycation endproducts, RAGE, is a multiligand receptor and NF-κB activator leading to perpetuation of inflammation. We investigated whether and how RAGE is involved in mediation of anti-inflammatory properties of protein C. METHODS AND RESULTS We analyzed the effect of protein C on leukocyte adhesion and transmigration in WT- and RAGE-deficient mice using intrav...

BACKGROUND L-type calcium channel activity is critical to afterload-induced hypertrophic growth of the heart. However, the mechanisms governing mechanical stress-induced activation of L-type calcium channel activity are obscure. Polycystin-1 (PC-1) is a G protein-coupled receptor-like protein that functions as a mechanosensor in a variety of cell types and is present in cardiomyocytes. METHOD...

Bacillus thuringiensis phosphatidylinositol-specific phospholipase C (PI-PLC), a bacterial model for the catalytic domain of mammalian PI-PLC enzymes, was cross-linked by 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride to probe for the aggregation and/or conformational changes of PI-PLC when bound to activating phosphatidylcholine (PC) interfaces. Dimers and higher order multimers (...

Eosinophils are involved in inflammatory diseases such as asthma. We previously reported that activated eosinophils increased the phosphatidylcholine (PC) secretion in primary cultures of rat type II pneumocytes. Increased PC secretion was confirmed to be partly mediated by superoxide anions released from activated eosinophils. However, the influence of eosinophil granule proteins on PC secreti...

In the present study, effects of NaCl concentrations (0, 20, 40 and 80 mM) were investigated in Ceratophyllum demersum. Macronutrients N, P and K and micronutrients Zn and Cu were significantly decreased by NaCl salinity. In general, however, Fe and Mn accumulation showed to increase. As a results, NaCl toxicity disturbed the uptake and translocation of macro and micronutrients in the macrophyt...