nanocomposite composed of organoclay(cloisite 20a-c20a) and poly lactic acid (pla) was prepared by solvent casting method. physical, mechanical, thermal, barrier and microstructure properties of the composite were studied. x-ray diffraction (xrd) patterns and scanning electron microscopy (sem) images revealed that the diffraction peak of nanoclay shifted to lower angles and the d-spacing betwee...

In this study, we developed NIR-light responsive poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) by incorporating the ICG dye for local delivery of small-molecular drugs and therapeutics. Since NIR light...

Despite being a simple dehydration reaction, the industrially relevant conversion of lactic acid to acrylic acid is particularly challenging. For the first time, the catalytic cracking of lactide and poly(lactic acid) to acrylic acid under mild conditions is reported with up to 58 % yield. This transformation is catalyzed by strong acids in the presence of bromide or chloride salts and proceeds...

In treatment of diabetes, it is much desired in clinics and challenging in pharmaceutics and material science to set up a long-acting drug delivery system. This study was aimed at constructing a new delivery system using thermogelling PEG/polyester copolymers. Liraglutide, a fatty acid-modified antidiabetic polypeptide, was selected as the model drug. The thermogelling polymers were presented b...

Abstract Wheat bran (WB) was investigated as potential filler for controlling the plasticizer migration in poly(lactic acid) (PLA)/poly(butylene succinate adipate) (PBSA) binary blends (with 60 wt.% of PLA and 40 PBSA). The process three different biobased biodegradable plasticizers [Triacetin (TA), acetyl tri- n -butyl citrate (ATBC) oligomeric lactic acid (OLA)] adding them at a fixed amount ...

Damage to peripheral nerves often cannot be repaired by the juxtaposition of the severed nerve ends. Surgeons have typically used autologous nerve grafts, which have several drawbacks including the need for multiple surgical procedures and loss of function at the donor site. As an alternative, the use of nerve guidance channels to bridge the gap between severed nerve ends is being explored. In ...

Introduction: The treatment of sagging skin in body areas is still a big challenge, as there are few aesthetic procedures aiming to improve it. The poly-L-lactic acid (PLLA) is an injectable synthetic polymer of the alpha-hydroxy acids family, which injection into the deep dermis or superficial hypodermis induces a local and gradual reaction, with synthesis of new collagen by the fibroblasts an...