نتایج جستجو برای: plc gene

تعداد نتایج: 1146437  

Journal: :Infection and immunity 2002
Catharina W Wieland Britta Siegmund Giorgio Senaldi Michael L Vasil Charles A Dinarello Giamila Fantuzzi

Chronic pulmonary infection with Pseudomonas aeruginosa is common in cystic fibrosis (CF) patients. P. aeruginosa lipopolysaccharide (LPS), phosholipase C (PLC), and exotoxin A (ETA) were evaluated for their ability to induce pulmonary inflammation in mice following intranasal inoculation. Both LPS and PLC induced high levels of tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1 ...

Journal: :The Journal of biological chemistry 1994
P A Ferreira W L Pak

The Drosophila norpA gene encodes a phosphatidylinositol-specific phospholipase C (PI-PLC) expressed predominantly in photoreceptors and involved in phototransduction. However, no direct role for a phospholipase C in vertebrate phototransduction has been identified to date. Recently, we reported the isolation and characterization of bovine cDNAs encoding PI-PLC isoforms expressed predominantly ...

Journal: :Infection and immunity 1999
S Merino A Aguilar M M Nogueras M Regue S Swift J M Tomás

Two different representative recombinant clones encoding Aeromonas hydrophila lipases were found upon screening on tributyrin (phospholipase A1) and egg yolk agar (lecithinase-phospholipase C) plates of a cosmid-based genomic library of Aeromonas hydrophila AH-3 (serogroup O34) introduced into Escherichia coli DH5alpha. Subcloning, nucleotide sequencing, and in vitro-coupled transcription-trans...

2005
Wolfgang Rottbauer Steffen Just Georgia Wessels Nicole Trano Patrick Most Hugo A. Katus Mark C. Fishman

The strength of the heart beat can accommodate in seconds to changes in blood pressure or flow. The mechanism for such homeostatic adaptation is unknown. We sought the cause of poor contractility in the heart of the embryonic zebrafish with the mutation dead beat. We find through cloning that this is due to a mutation in the phospholipase C 1 (plc 1) gene. In mutant embryos, contractile functio...

2014
Ali Dehghan-Noodeh Abdulshakor Nasir Geoff David Robson

BACKGROUND AND OBJECTIVES Phosphlipases are a group of enzymes that breakdown phosphatidylcholine (phospholipids) molecules producing second products. These produced products have a divers role in the cell like signal transduction and digestion in humans. In this research the effect of phosphatidylcholine on the expression of plc genes of A. fumigatus was studied. The plc genes of this fungus w...

Journal: :The EMBO journal 1999
S Katayama O Matsushita C M Jung J Minami A Okabe

The phospholipase C gene (plc) of Clostridium perfringens possesses three phased A-tracts forming bent DNA upstream of the promoter. An in vitro transcription assay involving C.perfringens RNA polymerase (RNAP) showed that the phased A-tracts have a stimulatory effect on the plc promoter, and that the effect is proportional to the number of A-tracts, and more prominent at lower temperature. A g...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1987
S H Ryu P G Suh K S Cho K Y Lee S G Rhee

We previously reported that cytosolic fractions of bovine brain contain two immunologically distinct forms of phospholipase C (PLC), PLC-I and PLC-II. We now report the purification of another form of inositolphospholipid-specific phospholipase C from bovine brain cytosol, designated PLC-III, and the comparison of the catalytic properties of the three isozymes. Approximately 450 micrograms of p...

2013
Nabila Djafi Chantal Vergnolle Catherine Cantrel Wojciech Wietrzyñski Elise Delage Françoise Cochet Juliette Puyaubert Ludivine Soubigou-Taconnat Delphine Gey Sylvie Collin Sandrine Balzergue Alain Zachowski Eric Ruelland

Phosphoinositide-dependent phospholipases C (PI-PLCs) are activated in response to various stimuli. They utilize substrates provided by type III-Phosphatidylinositol-4 kinases (PI4KIII) to produce inositol triphosphate and diacylglycerol (DAG) that is phosphorylated into phosphatidic acid (PA) by DAG-kinases (DGKs). The roles of PI4KIIIs, PI-PLCs, and DGKs in basal signaling are poorly understo...

2017
Guojun Tong Yue Meng Song Hao Shaoyu Hu Youhua He Wenjuan Yan Dehong Yang

BACKGROUND Parathyroid hormone (PTH) is an effective anti-osteoporosis agent, after binding to its receptor PTHR1, several signaling pathways, including cAMP/protein kinase A (PKA) and phospholipase C (PLC)/protein kinase C (PKC), are initiated through G proteins; with the cAMP/PKA pathway as the major pathway. Earlier studies have reported that PTHR1 might also activate PKC via a PLC-independe...

Journal: :Current Biology 1995
Reed C. Carroll Anthony D. Morielli Ernest G. Peralta

BACKGROUND One of the principal mechanisms by which G-protein-coupled receptors evoke cellular responses is through the activation of phospholipase C (PLC) and the subsequent release of Ca2+ from intracellular stores. Receptors that couple to pertussis toxin (PTX)-insensitive G proteins typically evoke large increases in PLC activity and intracellular Ca2+ release. In contrast, receptors that u...

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