BACKGROUND Pirfenidone (PFD) is a molecule that exhibits antifibrotic properties in a variety of in vitro and animal models of lung, liver and renal fibrosis. These pathologies share many fibrogenic pathways with an abnormal fibrous wound-healing process; consequently, tissue repair and tissue regeneration-regulating mechanisms are altered. OBJECTIVE To investigate the usefulness of PFD as an...

Prefoldin (PFD) is a jellyfish-shaped molecular chaperone that has been proposed to play a general role in de novo protein folding in archaea and is known to assist the biogenesis of actins, tubulins, and potentially other proteins in eukaryotes. Using point mutants, chimeras, and intradomain swap variants, we show that the six coiled-coil tentacles of archaeal PFD act in concert to bind and st...

This work is concerned with the prime factor decomposition (PFD) of strong product graphs. A new quasi-linear time algorithm for the PFD with respect to the strong product for arbitrary, finite, connected, undirected graphs is derived. Moreover, since most graphs are prime although they can have a product-like structure, also known as approximate graph products, the practical application of the...

The 2 out of 4-system (2oo4) is an advanced safety architecture. A 2oo4-system is 2-failure safe, this means that at least two of the four channels have to work correctly in order to trigger the safety function. In order to classify the quality of a system different parameters have to be calculated, like the PFD and MTTF. In this paper, equations are indicated for PFD for normal and common-caus...

In the literature radiofrequency (RF)-sympathectomy, percutaneous facet denervation (PFD), and percutaneous partial rhizotomy (PPR) have been described already in the seventies and eighties. However, a few years ago, papers have been published on thoracic PFD and PPR showing rather promising long term results. Anatomical considerations, indication, technique, results, and complications of these...

Atopic dermatitis (AD) is a chronic inflammatory skin disease resulting from excessive stimulation of immune cells. Traditionally, reactive oxygen species (ROS) have been implicated in the progression of inflammatory diseases, but several opposing observations suggest the protective role of ROS in inflammatory disease. Recently, we demonstrated ROS prevented imiquimod-induced psoriatic dermatit...

The extent to which PSII photoinactivation affects electron transport (PhiPSII) and CO2 assimilation remains controversial, in part because it frequently occurs alongside inactivation of other components of photosynthesis, such as PSI. By manipulating conditions (darkness versus low light) after a high light/low temperature treatment, we examined the influence of different levels of PSII inacti...

The purpose of the present is to measure and to compare the intraocular pressure (IOP) during manual and mechanical Perfluorodecalin (PFD) injection in 23 and 25-Gauge(G) simulated pars plana vitrectomy using a StellarisPC® vitrectomy system. A human eye model was developed and IOP recorded during infusion of PFD using three sensors, two located at the equator and one in an area corresponding t...

The process of computing correlation among attributes an ordinary database is significant in the analysis and classification a data set. Due to uncertainties embedded classification, encapsulating techniques using Pythagorean fuzzy information appropriate curb uncertainties. Although coefficient between (PFD) applicable measure, its output not reliable because intrinsic effect other interfering...

Background: Pipeline flow diverters (PFDs) are becoming increasingly common. Antiplatelet medication is required to minimize periprocedural ischemic events. Short-acting GPIIb/IIIa inhibitors frequently administered intraprocedurally; however, the role of these agents in postprocedural PFD management neurocritical care unit (NCCU) has been overlooked.Case Report: A patient with an unruptured in...