نتایج جستجو برای: permeation enhancer

تعداد نتایج: 29062  

2011
Deng-Guang Yu Li-Min Zhu Christopher J Branford-White Jun-He Yang Xia Wang Ying Li Wei Qian

BACKGROUND The objective of this investigation was to develop a new type of solid dispersion in the form of core-sheath nanofibers using coaxial electrospinning for poorly water-soluble drugs. Different functional ingredients can be placed in various parts of core-sheath nanofibers to improve synergistically the dissolution and permeation properties of encapsulated drugs and to enable drugs to ...

2017
Marcelle Silva-Abreu Lupe Carolina Espinoza María José Rodríguez-Lagunas María-José Fábrega Marta Espina María Luisa García Ana Cristina Calpena

Rosacea is the most common inflammatory skin disease. It is characterized by erythema, inflammatory papules and pustules, visible blood vessels, and telangiectasia. The current treatment has limitations and unsatisfactory results. Pioglitazone (PGZ) is an agonist of peroxisome proliferator-activated receptors (PPARs), a nuclear receptor that regulates important cellular functions, including inf...

2015
Xiang-Dong Duan Chang-Jiao Ji Lin Nie

Purpose: To develop transdermal patches of meloxicam (MLX) using chitosan and hydroxypropyl methylcellulose (HPMC) and polyvinyl alcohol (PVA) as hydrophilic polymers, polyamido amine (PAMAM) dendrimer as a permeation enhancer, and dibutyl pthalate as a plasticizer Methods: The patches were prepared by solvent casting evaporation technique using 3-factor, 3-level Box-Behnken design. The patches...

2013
Jun Shi Wen-Juan Cong Yi-Ming Wang Qing-Fei Liu Guo-An Luo

The aim of the present study was to investigate the influence and the mechanisms of cineole and terpineol on the in-vitro transdermal delivery of huperzine A from microemulsions, and their potential synergistic effect on the permeation enhancement. The transdermal delivery of huperzine A from microemulsions with different concentrations of cineole and terpineol through the rat abdominal skin wa...

2012
Mai Aldwaikat Mohammed Alarjah Jacki Willis Timothy Mason

Transdermal drug delivery is highly advantageous method for drug administration, yet the compact structure of stratum corneum is an effective barrier which limited the use of this route to very few drug molecules. Ultrasound enhances the permeation through the skin by altering this barrier function in a phenomenon named sonophoresis. This study aimed to evaluate the effect of variable ultrasoni...

Journal: :Biosciences, Biotechnology Research Asia 2022

The objective of the existing research was formulation development and preparation microemulsion loaded emulgel in augmenting topical delivery Lornoxicam. Emulsion gel combined are recognized as Emulgels. Gelling agents Carbopol 940, 974, 980 were used to formulating Lornoxicam emulgel. drug release from determined depending on different gelling agents. Clove oil for internal phase Polyethylene...

Afshin Zarghi, H Moghimi N Noorani

Many properties of chemicals depend on their streochemistry. Among these, the effects of streoisomerism on percutaneous absorption of drugs, which is subject of the present investigation, is not well studied yet. In this study, tretinoin (TT) and isotretinoin (ITT) (geometric isomers) were chosen and their permeations (alone or in the presence of each other) through enhancer-treated excised ...

Journal: :Drug development and industrial pharmacy 2010
Lei Wu Ge Zhang Qin Lu Qian Sun Mulan Wang Na Li Zidong Gao Ya Sun Tingting Li Deen Han Xue Yu Lei Wang Wei Sun Di Zhao Yaning Wu Yang Lu Xijing Chen

BACKGROUND Considering the chronic and repeated nature of salmon calcitonin (sCT) therapy, the oral route is a preferred route of administration. But, the oral bioavailability of sCT is very low due to enzymatic degradation and poor permeation across intestinal epithelial cells. It was the aim of this study to investigate the pharmacodynamic (PD), pharmacokinetic (PK), and mucosal injury charac...

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