BACKGROUND Sulfated polysaccharides from red marine algae have presented a variety of potentially therapeutic biological effects, however, their antinocicpetive and anti-inflammatory properties are not well understood. METHODS Male Swiss mice were pretreated with a sulfated polysaccharidic fraction obtained from the marine alga Acanthophora muscoides (AmII) (1, 3 or 9 mg/kg, iv) 30 min prior ...

The potential effects of flavonoids, phenylethanoid and neolignan glycosides from the aerial parts of Verbascum salviifolium Boiss. were studied in the p-benzoquinone-induced writhing reflex, for the assessment of the antinociceptive activity, and in carrageenan- and PGE1-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced ear edema models in mice, for the assessment of the a...

The aim of this study was to investigate the anti-inflammatory property of the ethanol extract of the root and rhizome of Pogostemon cablin (ERP). The anti-inflammatory effect was evaluated using four animal models including xylene-induced mouse ear edema, acetic acid-induced mouse vascular permeability, carrageenan-induced mouse pleurisy, and carrageenan-induced mouse hind paw edema. Results i...

Background: The potential edematogenic effect and the pharmacological characterization of a glucose-mannose-binding lectin from Dioclea violacea (DvL) were investigated. Methods: Paw edema was induced with DvL in control animals, and in animals pretreated with glucocorticoid or with blockers of histamine, nitric oxide synthase, cyclooxygenase, platelet activating factor (PAF), bradykinin and li...

The present study was aimed to the pharmacological screening some traditional Indian medicinal plants for its anti-inflammatory activity. The methanolic and aqueous extracts of leaves of Moringa oleifera and Ocimum gratissimum were taken and evaluated for their anti-inflammatory potential using carrageenan induced hind paw edema method. The methanolic and aqueous extracts of Ocimum gratissimum ...

the present study was designed to assess the cytotoxicity, anti-inflammatory and analgesic properties of methanol extract of woodfordia fruticosa flowers. cytotoxic activity of methanol extract of woodfordia fruticosa flowers was tested using artemia salina (brine shrimp) bioassay. two doses (400 and 600 mg/kg) were evaluated for the anti-inflammatory activity against the carrageenan, histamine...

background: advantages of herbal drugs have been known to human being for many years and they have been used for treatment of many diseases. nowadays, inflammation is known to be one of the basic pathologic causes of the diseases. objective: in this study the anti-inflammatory effect of thymus kotschyanus boiss & hohen was investigated. methods: forty two wistar rats were used in three divided ...

chalcone (1,3-diarylprop-2-en-1-one) derivatives have been introduced as selective cyclooxygenase-2 inhibitors. in the present study, anti-nociceptive and anti-inflammatory effects of eight novel compounds were evaluated in male mice and wistar rats by using the writhing and formalin-induced paw edema tests respectively. the activities of the compounds were compared with celecoxib as a referenc...

Anti-inflammatory activity of the ethanolic extract of the leaves of Morus indica Linn. was studied in wistar rats using the carrageenan induced left hind paw edema, carrageenan induced pleurisy and cotton pellet induced granuloma model. The ethanolic extract (100 mg/kg, p.o.) inhibited carrageenan induced rat paw edema. It also showed an inhibitory effect on leukocyte migration and a reduction...

Two [Met(0)6]deacetyl-thymosin beta4 analogs containing Phe(4F) or Tyr(Me) at position 12 were synthesized by the manual solid-phase method, and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw was studied. Fluorination of the para-position of Phe12 resulted in a marked antiinflammatory effect on carrageenin-induced edema in the mouse paw compared with that of our sy...