Massive symmetrical calcification of the basal ganglia and dentate nuclei is now a well recognized radiological finding and great emphasis has been laid on its association with hypoparathyroidism (Lowenthal, 1948). While such an association is undeniable the connexion between the two phenomena is ill understood and cannot at present be accepted as invariable. It is the purpose of this paper to ...

Background Depression, a challenging disorder, affects 1–6% of adolescents and early onset often predicts more serious manifestations in later life. Elevated Parathyroid hormone (PTH), parathormone levels have reported among adults with depression. In this study, the roles of 25(OH) D (vitamin D) and parathormone during adolescence, in which the frequency of depression is high, were studied. Ma...

BACKGROUND Diminished bone mineral density (BMD) is a well known complication in women with classic galactosaemia caused by premature ovarian failure. Diminished BMD in prepubertal patients of either sex has, however, only been reported once. AIM To assess BMD in children with classic galactosaemia. METHODS Eleven treated patients (five males, six females, aged 2-18 years) had BMD determine...

The remarkable diagnostic difficulty in the parathyroid disorders has induced many authors to study tests of dynamic investigation of this gland in order to detect functional changes. The most widely employed dynamic investigation tests of the parathyroid may be schematically considered as divided into: stimulation tests , inhibition tests and calcium turnover determination tests. The prednison...

BACKGROUND Primary hyperparathyroidism is caused by the excessive growth of parathormone secretion, its consequence being hypercalcemia. The parathyroid adenoma is responsible for over half of primary hyperparathyroidism cases. The mandibular tumor can be the initial sign in the case of primary hyperparathyroidism. CASE PRESENTATION We present the case of a 33 year old patient with history of...

The typical sonomorphology of homogeneously hypoechoic texture of an enlarged parathyroid gland (PG) is a reflection of uniform arrangement of the parathormone-producing chief cells. A variable cellular arrangement, hemorrhage, fibrosis, and adipocytes cause heterogeneous appearance. We describe a case of a 32-year-old male, a case of tertiary hyperparathyroidism, with increased serum parathorm...

Primary hyperparathyroidism (PHPT) is caused by excessive autonomous secretion of parathormone (PTH), usually as a result of a parathyroid adenoma (80-85%), and less frequently due to parathyroid gland hyperplasia (15%-20%) or carcinoma (1%) (Kaplan et al.1991). Patients often suffer from mild subjective symptoms such as weakness and tiredness, but if untreated, symptoms progess to include deme...

Nine patients with acute leukaemia developed a complex syndrome of hypocalcaemia and hypomagnesaemia during treatment. These metabolic abnormalities developed rapidly in some patients and gave rise to acute symptoms. Immunoreactive parathormone concentrations in these patients were found to be either absolutely or inappropriately low. Hypomagnesaemia and the action of chemotherapeutic agents, e...

In an earlier, rather extensive, publication in this journal on the "Functional Pathology of Hyperparathyroidism " (1) no mention wasmade of magnesium metabolism. Data have now been collected permitting a contribution to this phase of the subject. The methods of study were the same as described in the previous paper (1). Magnesium determinations were made by the procedure outlined by Briggs (2)...

Kidney histology of five infants who died during or immediately after treatment with adrenocorticotrophic hormone (ACTH) showed severe tubular and interstitial calcinosis. We therefore studied serum concentrations of calcium, inorganic phosphate, and parathormone, serum activities of alkaline phosphatase, and urinary excretion of calcium, inorganic phosphate, and cyclic adenosine monophosphate ...