Extramammary Paget disease (EMPD) is a rare cutaneous neoplasm. Perianal Paget disease (PPD) is a subset of EMPD manifesting perianal lesions. Two cases of PPD in Severance Hospital are described in this article. A 65-year-old female and 78-year-old male patients visited our institution because of an unhealed perianal skin lesion despite treatment for a long period with topical agents. PPD was ...

OBJECTIVE To emphasize the importance for health care professionals to be knowledgeable of a relatively rare form of thoracic outlet syndrome, known as Paget Schroetter syndrome. The etiology, key signs and symptoms, and the importance of immediate referral are highlighted and an introduction to manual therapists' role within a multidisciplinary team is provided. CLINICAL FEATURES Healthy ath...

INTRODUCTION A journal club (JC) is defined as a group of individuals who meet regularly to critically discuss the applicability of current peerreviewed articles published in medical journals. The memoirs of Sir James Paget, a surgeon at St Bartholomew’s Hospital, London, UK (1835–54), contain the earliest mention of a JC. Sir Paget described ‘a kind of club in a small room over a baker’s shop ...

The aim of this work is to report the histopathological features of jaw bone in 24 cases of bisphoshonate-related osteonecrosis of the jaw. In all cases, lamellar bone trabeculae were thicker (bone sclerosis), had no osteocytes in the lacunae (bone necrosis), and exhibited a Pagetlike structure with marked signs of bone remodeling and formation of multiple trabecular compartments that were not ...

Introduction—Mutations in the valosin containing protein (VCP) gene cause hereditary Inclusion Body Myopathy (hIBM) associated with Paget disease of bone (PDB), and frontotemporal dementia (FTD). More recently they have been linked to 2% of familial ALS cases. A knock-in mouse model offers the opportunity to study VCP-associated pathogenesis. Methods—The VCPR155H/+ knock-in mouse model was asse...

BACKGROUND At 5-year follow-up, patients with Paget disease of the breast who were treated with breast-conserving surgery (BCS) and radiotherapy (RT) had excellent results. The current report provides 10- and 15-year rates of tumor control in the breast, as well as disease-free and overall survival rates following BCS and RT in a cohort of patients with Paget disease presenting without a palpab...

Paget-Schroetter Syndrome is a rare condition characterized by the thrombosis of axillary and/or subclavian vein due to repetitive activity upper extremity. This effect results in exertion-induced deep venous (DVT) In literature, it has been reported more frequently among adult population. We aimed introduce 15-year-old female patient who suffered an acute DVT left extremity, and her successful...