Background: Breast carcinoma is the most common malignancy in women world. This study evaluated expression of ER, PR and p53 breast its correlation with age, size, lymph node status other parameters. Methods: 103 histologically proven cases were subjected to IHC for ER,PR p53. Result: Total cancer 103. All between 21-60 years tumour size varying from 0.5->5cm. Maximum grade III. Metastatic carc...

background there is evidence of a possible etiological role of human papillomaviruses (hpvs) in the development of colorectal cancer. loss of p53 tumor suppressor gene function has been found in many malignancies and it can occur in a variety of ways, including gene mutation and interaction with the e6 protein of oncogenic hpvs. the objective of this study was to determine the prevalence of hpv...

Background: P53 tumor suppressor gene mutation is one of the most common genetic alterations in human malignancies. The mutated from of the gene is stable and can be detected with immunohistochemistry methods. There is much controversy about the expression rate of this gene in malignant melanoma. Objective: To determine the frequency of the P53 antigen expression by sex, age, type and thickness...

background: colorectal adenocarcinoma is one of the most prevalent and treatable malignancies of the gastrointestinal tract. pattern of expression of the p53, p21, p16, e-cadherin and |î²|-catenin proteins are shown to be related to the prognosis of this malignancy. we aimed to compare the pattern of expression of these proteins in tumoral and nontumoral mucosal cells of cancer and on-cancer pa...

background and aim: squamous cell carcinoma is the eighth common cancer and forms 94% of oral malignancies. nowadays, many molecular and genetic changes have been known to affect tumoral behavior which might be good for drug production and gene therapy. it has been known that mutated p53, overexpression of p63 as an oncogene and hpv infection are correlated with clinicopathological behavior of ...

Abstract Background: Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1).  HTLV-1 oncogenes can induce malignancy through controlled gene expression of cell cycle checkpoints in the host cell. HTLV-I genes play a pivotal role in overriding cell cycle checkpoints and deregulate cellular division. In this study, we aimed to determine and comp...

Recent studies have shown that FMS-like receptor tyrosine kinase 3 (Flt3) has a beneficial effect on cardiac maladaptive remodeling. However, the role and mechanism of Flt3 in mitochondrial dynamic imbalance under stress remains poorly understood. This study aims to investigate how regulates p53-mediated optic atrophy 1 (OPA1) processing fragmentation improve Mitochondrial cardiomyocytes was in...

Background: Nano-particle Titanium Dioxide (TiO2) is a noncombustible, odorless powder that is widely used in different fields of industries. Previous reports showed that chronic exposure to TiO2 adversely impacts the testicular tissue and down-regulates the antioxidant capacity and down-regulates the endocrine status of the testicles. Present study was designed in order to identify the role of...