To investigate the effect of shikonin on oxidative damage lung cancer cells and promotes cell senescence through p53/p21Waf signaling pathway. The adenocarcinoma A549 were cultured made into suspension. for 12 h, 24 h 48 respectively with different concentrations (0 μm, 2 μm 4 μm) activity was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide method. cycle each group mea...

Background: Cancer is a major cause of death worldwide. One the most common forms cancer oral cancer, which can occur due to exposure carcinogenic factors, such as tobacco cigarettes, alcohol, betel-nut chewing, ultraviolet rays or human papillomavirus infection. Physical exercise known have many benefits and contribute reducing risk minimising side-effects treatment increasing curative effect ...

Objective(s): This study focused on determining cytotoxic effects of copper oxide nanoparticles (CuO NPs) on chronic myeloid leukemia (CML) K562 cell line in a cell-specific manner and its possible mechanism of cell death. We investigated the cytotoxicity of CuO NPs against K562 cell line (cancerous cell) and peripheral blood mononuclear cell (normal cell). Materials and Methods: The toxicity w...

Background: Quercetin has been reported to modulate cell proliferation and apoptosis. The present study aimed at identifying whether treatment of ionizing radiation (IR) combined with quercetin induces apoptosis in HepG2 cells. Materials and Methods: HepG2 cells were plated at an appropriate density according to each experimental scale and irradiated with 1, 5 and 10 Gy gamma-rays from a 60Co s...

Background: P53, p63, and p73 transcription factors which are belong to The p53 family, are conserved during evolution. They have important roles in many molecular and cellular functions, including tumor suppression, the development of epithelial cell layers, and the development of central nervous system and immune system. Studies show these molecules also have role in maintaining the genomic i...

BACKGROUND: Cellular senescence is a stress response, triggered by various stimuli such as chemotherapy treatment and causes G0/G1 cell cycle arrest followed the production of associated secretory phenotype. p53 considered to be modulator these events although precise mechanisms it remains not clear.
 AIMS: To determine non-apoptotic functions protein formation phenotype melanoma cells und...

Abstract Calorie restriction (CR) without malnutrition is a dietary intervention where energy intake reduced by 15 – 40%. The benefits of CR in improving various diseases and extending lifespan has led its investigation cancer. We have reported 30% to limit epithelial ovarian cancer (EOC) progression. Here, we highlight the ability induce immuno-metabolic reprogramming tumor associated macropha...

an 11 year – old mixed female labrador was presented with two masses in trunk and neck. the tumoral masses were excised and sent for histopathological and immunohistochemical analyses. histopathological examination of masses revealed diffuse infiltration of small sized lymphoid cells in subcutaneous tissue which were intense around the blood vessels. more than 10% lymphoid cells were cd3 positi...

Abstract Genotoxic colibactin-producing pks + Escherichia coli induce DNA double-strand breaks, mutations, and promote tumor development in mouse models of colorectal cancer (CRC). Colibactin’s distinct mutational signature is reflected human CRC, suggesting a causal link. Here, we investigate its transformation potential using organoids from primary murine colon epithelial cells. Organoids rec...