Saururus chinensis (SC), a traditional medicine, has been used for the treatment of edema, jaundice, gonorrhea, and several inflammatory diseases in China Korea. Our previous studies reported anti-osteoporotic activity SC extract (SCE) ovariectomized (OVX) rats but mechanism this effect was unclear. The aim study to explore SCE elucidate underlying mechanisms using metabolomics approach based o...

It has been previously reported (7) that the administration of estrogens to the ovariectomized rat causes a pronounced response in the peroxi dase level of the uterus. Since the estrogens stimu late mitotic activity in the uterus, it was thought that the presence of peroxidase might be charac teristic of tissues undergoing proliferation. The studies to be presented in this paper mdi cate that a...

We report the consequences of prolonged treatment with recombinant human parathyroid hormone (1-34) (PTH) in male and ovariectomized female rats with mature skeletons. Intact male and osteopenic, ovariectomized, female F-344 rats were evaluated after 1 year of treatment with 0, 8, or 40 microg/kg/day s.c. PTH. Males and females were about 6 months of age at study initiation; females were ovarie...

Changes in rat urerine luminal proteins were analysed during pregnancy and after ovariectomy on Day 3 of pregnancy plus daily administration of progesterone, when delay of implantation is imposed. Total protein levels reached a peak level on Day 5 of pregnancy, the day of implantation, in the intact but not the ovariectomized females. Qualitative analyses of protein-SDS complexes showed an incr...

BACKGROUND The densely staining sexually dimorphic nucleus of the preoptic area (SDNPOA) is profoundly affected by gonadal steroids during perinatal development. METHODS We tested whether the SDNPOA in rats also remains responsive to gonadal hormones in adulthood. RESULTS Castration of 60-day-old male rats led to a reduction of soma size in SDNPOA neurons 28 days later, but not 14 days late...

Background: The ovariectomized animals are good models to evaluate the effect of different steroid hormone treatments on implantation events and the pattern of integrin expression. Therefore, this study was performed to compare the expression of integrins and osteopontin (OPN) in correlation with pinopode development in ovariectomized mice endometrium which was subjected to steroid hormones. Me...

2ƒ¿,3ƒ¿-Epithio-5ƒ¿-androstan-17ƒÀ-ol (10275-S) has been known to possess a potent and long-acting anti-estrogenic activity in rodents. In this experiment, 1.25mg 10275-S injected once subcutaneously into the ovariectomized and estradiol-treated mice caused a complete block of vaginal cornification for 24.3 days in spite of the successive treatment with estrogen. Pre-treatment with 10275-S in o...

Materials and methods: The study was performed in 5 groups of rat tracheal smooth muscle obtained during proestrus, estrus, metestrus, and diestrus phases of the estrous cycle, as well as the ovariectomized group (n:8/group). Cumulative acetylcholine contractions ranging from 10 to 10 M bath doses and the cumulative isoproterenol relaxations ranging from 10 to 10 M precontracted with 10 M of ac...

After systemic administration of several serotonergic antagonists, female rats that had been ovariectomized, adrenalectomized, and estrogen-primed showed lordotic responding. Lordosis could also be elicited after direct placement of serotonergic receptor blockers into hypothalamic sites known to contain serotonergic terminals. None of the treatments activated the soliciting component of the est...