Functional gastrointestinal disorders (FGIDs) are diagnosed and classified using the Rome criteria; the criteria may change over time as new scientific data emerge. The Rome IV was released in May 2016. The aim is to review the main changes in Rome IV. FGIDs are now called disorders of gut-brain interaction (DGBI). Rome IV has a multicultural rather than a Western-culture focus. There are new c...

Background: Opioid use disorder is a major concern to public health, and opioid maintenance treatment onmethadone or buprenorphine is a widely used approach. On the other hand, in recent years, there has beenmore regards for the use of opium tincture for detoxification and maintenance treatment of opioiddependence in certain parts...

background: there is evidence that pulmonary function abnormalities are present in patients with inflammatory bowel disease (ibd). the aim of this case-control study was to assess the frequency of pulmonary dysfunction in patients with ibd. materials and methods: pulmonary function of 37 patients with ibd (8 with cd and 29 with uc) without any known pulmonary disease was tested by body-box plet...

INTRODUCTION Use of opiates/opioids is associated with hypoactive sexual desire, erectile and orgasmic dysfunction. AIM To determine prevalence and investigate etiology of sexual dysfunction in men on methadone or buprenorphine maintenance treatment (MMT, BMT). MAIN OUTCOME MEASURES International Index of Erectile Function (IIEF), hormone assays, Beck Depression Inventory. METHODS A total...

Introduction: According to evidence, Early-Life Stress (ELS), mood disorders, and medical comorbidities, i.e.  Irritable Bowel Syndrome (IBS), are correlated; however, the direct contribution of ELS to IBS manifestations is less understood. The current study aimed at evaluating the effect of voluntary exercise on the mitochondrial dysfunction of the bowel fibroblasts, following the confirmation...