A 71-year-old woman was referred to our clinic with a 2-month history of pain and exudate from her right first toe. Physical examination revealed subungual nodule that elevated the nail plate produced distal onycholysis. We performed onychectomy removed nodule. histopathological specimen showed hyperkeratosis acanthosis in epidermis, papillomatosis dilated vessels superficial dermis, aggregatio...

In recent years, the widespread use of taxane-based chemotherapy regimens for the management of malignant tumors of various origins has evidenced the high frequency of cutaneous toxicity induced by this pharmacological group. In 2003, among its possible manifestations, Childress and Lokich defined periarticular thenar erythema and onycholysis (PATEO) syndrome as a rare subtype of hand-foot synd...

Abstract Erythropoietic protoporphyria (EPP) is usually caused by autosomal dominant mutations in FECH: raised protoporphyrin levels cause itching, burning and erythema after sun exposure, with facial scarring sometimes liver damage. We report a child the much rarer X-linked form (XLDPP) consider reasons for his unusually severe features. A 4-year-old boy living India presented long-standing er...