PURPOSE To investigate the optical intensities of all retinal layers on three-dimensional (3D) spectral-domain optical coherence tomography (SD-OCT) in normal subjects using an automatic measurement. METHODS Forty normal subjects underwent Topcon 3D OCT-1000 macula-centered scan. The raw data were automatically segmented into 10 layers using the 3D graph search approach. Then the mean and sta...

PURPOSE TUNEL assay is widely used to evaluate cell death. Quantification of TUNEL-positive (TUNEL+) cells in tissue sections is usually performed manually, ideally by two masked observers. This process is time consuming, prone to measurement errors, and not entirely reproducible. In this paper, we describe an automated quantification approach to address these difficulties. METHODS We develop...

In this project, we study the degree of loss synchronization between TCP connections sharing a bottleneck network link, i.e., the fraction of the connections that lose a packet during a congestion instance. Loss synchronization determines the variability of the total TCP load on the link and therefore affects the loss, delay, and throughput characteristics of network applications. We conduct ou...

Although dry age-related macular degeneration (AMD) is one of the major causes of blindness, no effective therapies are developed. In this study, we investigated the effects of SUN N8075, a radical scavenger with neuroprotective properties, against light-induced retinal damage used as the model of dry AMD in mice. After dark adaption for 24 h, we exposed the mice at 8000 lx for 3 h. We evaluate...

Spectral domain optical coherence tomography (SD-OCT) was performed in two cases of bilateral X linked foveal retinoschisis of different age groups. On fundus examination spoke wheel and honeycomb pattern of cysts were observed along with retinal nerve fibre layer (RNFL) defects. On SD-OCT, schisis was observed in the outer plexiform layer. External limiting membrane disruption was observed in ...

Iron is a constitulenit of the hemiie of catalase, cvtochroniie oxidase and peroxidase and( iron deficiency is kinow-n to del)ress iron l)orphyriln enzymlies ( 1. 3. 9. 14, 22, 27. 35). There is hardly any informiiationi onl the effect of iron supply on enzymes for which iron is not a cofactor. The work presented here was primarily carried out to investigate the effect of graded levels of iron ...

Using the example of Taking a Stand in Cyberspace , we art iculate i s sues confront ing school , community, and higher education groups as they create onl ine discuss ions geared to deepen the leve l of s tudent discourse about l i terature. Through a col laboration between the Vermont Center for the Book, the WEB Project , and six Vermont schools , students read and discussed three books whi ...

We have investigated the role of nitric oxide (NO) in the rat retina following ischemic injury induced by transient increase of intraocular pressure. The thickness of both the inner plexiform layer and inner nuclear layer decreased during early postischemic stages (up to 1 week). In late postischemic stages (2-4 weeks), the thickness of the outer nuclear layer (ONL) decreased markedly. Thus, me...