Abstract Background Childbirth is a life-transforming intense event to woman and her family. Even though variety of non-pharmacological techniques are readily available alleviate the distress women in labour, majority unaware its benefits. The objective study was explore impact simple technique i.e., antepartum brea...

Despite the gain in sustained virological responses (SVR) provided by protease inhibitors (PIs), failures still occur. The aim of this study was to determine if a baseline analysis of the NS3 region using ultradeep pyrosequencing (UDPS) can help to predict an SVR. Serum samples from 40 patients with previously nonresponding genotype 1 chronic hepatitis C who were retreated with triple therapy, ...

Background: Exagerated immune activation has a key role in the pathogenesis of malaria. During blood-stage infection, Plasmodium falciparum can interact directly with host cells through infected red blood (PfiRBCs), or indirectly by release extracellular vesicles (EVs). Here, we compared impact <n...

Aims: The aim of the study was to reveal variability in soil properties influencing pigeonpea (Cajanus cajana L.) seed yield under semi-arid rainfed condition. Methods: Soils were initially classified into series level and further these divided soil-phase units. For two site years viz.</ns3:ital...

A series of mouse monoclonal antibodies (MAbs) to the nonstructural protein 3 (NS3) of hepatitis C virus was prepared. One of these MAbs, designated 8D4, was found to inhibit NS3 protease activity. This inhibition was competitive with respect to the substrate peptide (K(i) = 39 nM) but was significantly decreased by the addition of the NS4A peptide, a coactivator of the NS3 protease. 8D4 also s...

The hepatitis C virus (HCV) nonstructural 3 (NS3) protein is composed of an amino terminal protease and a carboxyl terminal RNA helicase. NS3 contains major antigenic epitopes. The antibody response to NS3 appears early in the course of infection and is focused on the helicase region. However, this response cannot be defined by short synthetic peptides indicating the recognition of conformation...

The NS3 protein of hepatitis C virus (HCV) possesses protease activity responsible for the proteolytic cleavage of the viral polyprotein at the junctions of nonstructural proteins downstream of NS3. The NS3 protein was also found to be internally cleaved. In this study, we demonstrated that internal cleavages occurred on the NS3 protein of genotype 1b in the presence of NS4A, both in culture ce...

Molecular characterization of bovine viral diarrhea virus pair 13 revealed that isolate CP13 is composed of a cytopathogenic (cp) defective interfering particle (DI13) and a noncytopathogenic (noncp) helper virus. The DI13 genome possesses two internal deletions of 1,611 and 3,102 nucleotides. Except for a small fragment of the gene coding for glycoprotein E1, all structural protein genes are d...

Background Directly Observed Treatment (DOT) is a requirement in the management of Tuberculosis (TB) globally. With transition from alternate day treatment to daily India, monitoring adherence through DOT logistic challenge. The pervasiveness mobile phones India provides unique opportunity address this challenge remotely. This ...

Background: During pregnancy, the placenta is an extremely important organ as it secretes its own hormones, e.g. insulin-like growth factor 1 (IGF-1), to ensure proper intrauterine fetal and development. Ethanol, addictive widely used drug, has numerous adverse effects during including restriction (FGR). To date, molecular mechanisms by which...