نتایج جستجو برای: normoxia

تعداد نتایج: 2771  

Journal: :Journal of applied physiology 2001
T Ogasa H Nakano H Ide Y Yamamoto N Sasaki S Osanai Y Akiba K Kikuchi J Iwamoto

The effects of changing perfusate flow on lung nitric oxide (NO) production and pulmonary arterial pressure (Ppa) were tested during normoxia and hypoxia and after N(G)-monomethyl-L-arginine (L-NMMA) treatment during normoxia in both blood- and buffer-perfused rabbit lungs. Exhaled NO (eNO) was unaltered by changing perfusate flow in blood-perfused lungs. In buffer-perfused lungs, bolus injecti...

2015
Daniel Verduzco Mark Lloyd Liping Xu Arig Ibrahim-Hashim Yoganand Balagurunathan Robert A. Gatenby Robert J. Gillies

Hypoxia in tumors correlates with greater risk of metastases, increased invasiveness, and resistance to systemic and radiation therapy. The evolutionary dynamics that links specific adaptations to hypoxia with these observed tumor properties have not been well investigated. While some tumor populations may experience fixed hypoxia, cyclical and stochastic transitions from normoxia to hypoxia ar...

2015
Merih Cetinkaya Mehmet Cansev Ferhat Cekmez Cuneyt Tayman Fuat Emre Canpolat Ilker Mustafa Kafa Esra Orenlili Yaylagul Boris W. Kramer Serdar Umit Sarici

OBJECTIVE Histone acetylation and deacetylation may play a role in the pathogenesis of inflammatory lung diseases. We evaluated the preventive effect of valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, on neonatal hyperoxic lung injury. METHODS Forty newborn rat pups were randomized in normoxia, normoxia+VPA, hyperoxia and hyperoxia+VPA groups. Pups in the normoxia and normoxia+VP...

2017
Matthew I. Black Christopher R. Potter Jo Corbett Cain C. T. Clark Stephen B. Draper

Highly aerobically trained individuals are unable to achieve maximal oxygen uptake ([Formula: see text]) during exhaustive running lasting ~2 min, instead [Formula: see text] plateaus below [Formula: see text] after ~1 min. Hypoxia offers the opportunity to study the ([Formula: see text]) response to an exhaustive run relative to a hypoxia induced reduction in [Formula: see text]. The aim of th...

2010
Samuel Verges Damien Bachasson Bernard Wuyam

BACKGROUND Greater diaphragm fatigue has been reported after hypoxic versus normoxic exercise, but whether this is due to increased ventilation and therefore work of breathing or reduced blood oxygenation per se remains unclear. Hence, we assessed the effect of different blood oxygenation level on isolated hyperpnoea-induced inspiratory and expiratory muscle fatigue. METHODS Twelve healthy ma...

Journal: :Iranian journal of allergy, asthma, and immunology 2015
Zohreh Safari Reza Safaralizadeh Mir Hadi Seyedzadeh Ayla Valinezad Orang Ahad Zare Mohammad Ali Hosseinpour Feizi Gholam Ali Kardar

It is aimed to evaluate the actual anti-cancerous effects of metformin on cancer cells in hypoxic condition. Non-cancerous cells (HEK293) and cancer cells (MCF-7) were cultured in both hypoxia and normoxia conditions and treated with different concentrations of metformin. The proliferation, apoptosis, and necrosis rate were assessed using MTT test and Annexin V assay. The S6K1 phosphorylation w...

Journal: :The Journal of physiology 2008
Ioannis Vogiatzis Dimitris Athanasopoulos Robert Boushel Jordan A Guenette Maria Koskolou Maroula Vasilopoulou Harrieth Wagner Charis Roussos Peter D Wagner Spyros Zakynthinos

We investigated whether the greater degree of exercise-induced diaphragmatic fatigue previously reported in highly trained athletes in hypoxia (compared with normoxia) could have a contribution from limited respiratory muscle blood flow. Seven trained cyclists completed three constant load 5 min exercise tests at inspired O(2) fractions (FIO2) of 0.13, 0.21 and 1.00 in balanced order. Work rate...

2016
Igor B. Mekjavic Mojca Amon Roger Kölegård Stylianos N. Kounalakis Liz Simpson Ola Eiken Michail E. Keramidas Ian A. Macdonald

To assess the effect of normobaric hypoxia on metabolism, gut hormones, and body composition, 11 normal weight, aerobically trained (O2peak: 60.6 ± 9.5 ml·kg(-1)·min(-1)) men (73.0 ± 7.7 kg; 23.7 ± 4.0 years, BMI 22.2 ± 2.4 kg·m(-2)) were confined to a normobaric (altitude ≃ 940 m) normoxic (NORMOXIA; PIO2 ≃ 133.2 mmHg) or normobaric hypoxic (HYPOXIA; PIO was reduced from 105.6 to 97.7 mmHg ove...

2002
F. C. MARK C. BOCK

Mark, F. C., C. Bock, and H. O. Pörtner. Oxygen limited thermal tolerance in Antarctic fish investigated by MRI and 31P-MRS. Am J Physiol Regul Integr Comp Physiol 283: R1254–R1262, 2002. First published August 8, 2002; 10.1152/ajpregu.00167.2002.—The hypothesis of an oxygenlimited thermal tolerance was tested in the Antarctic teleost Pachycara brachycephalum. With the use of flow-through respi...

2013
Wei Li Zhen-Fu Hu Bin Chen Guo-Xin Ni

BACKGROUND Oxygen and glucose are two important nutrients for mammalian cell function. In this study, the effect of glucose and oxygen concentrations on C2C12 cellular metabolism was characterized with an emphasis on detecting whether cells show oxygen conformance (OC) in response to hypoxia. METHODS After C2C12 cells being cultured in the levels of glucose at 0.6 mM (LG), 5.6 mM (MG), or 23....

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