The steepest descent (SD) method is well-known as the simplest in optimization. In this paper, we propose a new SD search direction for solving system of linear equations Ax = b. We also prove that proposed with exact line satisfies condition and possesses global convergence properties. This motivated by previous work on Zubai’ah-Mustafa-Rivaie-Ismail (ZMRI)[2]. Numerical comparisons classical ...

German sentences with man and Italian si impersonale or passivante are often presented as equivalent in contrastive grammars. However, this functional equation proves to be problematic when students refer their own role authors, such in: “Darauf wird aber im folgenden Kapitel eingehen”. Evidently, cannot the speaker role, while same context is well suitable. Starting from interference error, pa...

PURPOSE We recently demonstrated that molecular therapy using aminoglycosides can overcome the underlying genetic defect in two zebrafish models of ocular coloboma and showed abnormal cell death to be a key feature associated with the optic fissure closure defects. In further studies to identify molecular therapies for this common congenital malformation, we now examine the effects of anti-apop...

The midbrain-hindbrain domain (MH) of the vertebrate embryonic neural tube develops in response to the isthmic organizer (IsO), located at the midbrain-hindbrain boundary (MHB). MH derivatives are largely missing in mutants affected in IsO activity; however, the potentialities and fate of MH precursors in these conditions have not been directly determined. To follow the dynamics of MH maintenan...

The basal level of the gene expression and the activity of 3-hydroxy3-methylglutaryl coenzyme A (HMG CoA) reducÃ-asewas higher in SV40-transformed human fibroblasts (90-VA VI) than in normal ones (HDF). In both these cell types mevinolin (25 /IM) caused an 85-90% depression of HMG CoA reducÃ-aseactivity and of the incorporation of [•'Hjacetate into sterols. In HDF this was coupled to an effic...