A case of a localized testicular abscess due to Nocardia asteroides in a patient on immunosuppressive therapy for a myeloproliferative disorder is reported. Subsequent fatal dissemination of the infection to the prostate, lungs, and liver occurred. This represents the second reported case of nocardiosis of the testis. Extrapulmonary forms of nocardiosis must be recognized so that appropriate tr...

Background: Nocardia is a Gram-positive and partially acid-fast bacterium. The species are widely distributed in the environment cause severe human infections. Nocardiosis not easily identifiable due to lack of pathognomonic clinical signs. Objectives: present study was designed develop evaluate simple quick method based on loop-mediated isothermal amplification (LAMP) assay for detecting spp i...

BACKGROUND Cushing's syndrome results from exposure to excess glucocorticoids. Ectopic Cushings is endogenous ACTH dependant form of Cushing's associated with markedly raised ACTH and cortisol levels. This leads to an impaired immune response, setting the stage for occurrence of opportunistic infections. Nocardiosis is a gram positive bacterial infection caused by aerobic actinomycetes in genus...

Nocardia species do not replicate as rapidly other pyogenic bacteria and nocardial infections can be highly fatal, particularly in immunocompromised patients. Here, we present the first report of fatal kroppenstedtii bacteremic pneumonia empyema thoracis diagnosed by next-generation sequencing (NGS) using Oxford Nanopore Technologies' MinION device. The bacterium was identified matrix-assisted ...

Nocardia are Gram-positive filamentous bacteria responsible for infections ranging from opportunistic life-threatening disseminated diseases to chronic skin and soft-tissue infections.Even if virtually all organs can be infected, articular involvement is rare. Therefore, we report 3 recent cases and performed a literature review of cases of Nocardia arthritis in order to describe clinical featu...

We report a case of nocardiosis in an immunosuppressed elderly patient who presented with prolonged pyrexia. Nocardia asteroides was isolated from the thyroid, with CT scan evidence of dissemination to the brain, abdomen and lungs. The patient succumbed to illness despite aggressive therapy. Autopsy could not be performed. To the best of our knowledge, this is the first reported case from India...

Nocardia species are aerobic, gram-positive, filamentous, partially acid-fast actinomycetes which are found worldwide in soil and decaying organic plant matter. When they infect human beings, they generally enter through the respiratory tract and then disseminate systemically. Rarely has a primary infection occurred as the result of direct inoculation. Isolation of Nocardia from clinical specim...

Complement-fixing antibody was detected in 13 of 16 patients with histological and/or culture evidence of infection with Nocardia species. The antigen used was a filtrate of soluble substances secreted into liquid growth medium by cultures of N. asteroides. Apparent false positives reactions were found in three of three patients with leprosy and two of five patients with tuberculosis--results ...

Nocardia species are found in soil rich in organic matter and in healthy gingiva, as well as periodontal pockets as oral microflora. Some species are pathogenic with low virulence, hence cause opportunistic infection most frequently in immunocompromised hosts, though occasionally in immunocompetent individuals. Pleuropulmonary nocardiosis is a rare occurrence. We report such a case in a 72yrs o...