نتایج جستجو برای: neurotoxicity syndromes
تعداد نتایج: 85645 فیلتر نتایج به سال:
Institute of Biomedicine, University of Gothenburg, SE-405 30 Gothenburg, Sweden; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, SE-751 25 Uppsala, Sweden; and Department of Molecular Biology, Swedish University of Agricultural Sciences (SLU), Uppsala Biomedical Center, SE-751 2...
Four cases of cauda equina syndrome occurring after continuous spinal anesthesia are reported. In all four cases, there was evidence of a focal sensory block and, to achieve adequate analgesia, a dose of local anesthetic was given that was greater than that usually administered with a single-injection technique. We postulate that the combination of maldistribution and a relatively high dose of ...
study is its methodological simplicity. Lesion studies are often thought not to be informative about processing mechanisms; in other words they are often thought to answer the question ‘‘What does this area do?’’ rather than the (harder) question of ‘‘How does it do it?’’ But in using a wellstudied behavioral paradigm for testing discrimination learning in rodents and straightforward neurotoxic...
The dependence of disease risk and age-of-onset on expanded CAG repeat length in diseases like Huntington's disease (HD) is well established and correlates with the repeat-length-dependent nucleation kinetics of polyglutamine (polyGln) aggregation. The wide variation in ages of onset among patients with the same repeat length, however, suggests a role for modifying factors. Here we describe the...
Neurotoxic esterase (NTE), the putative target for organophosphorus-induced delayed axonopathy, has been found in preparations of human placenta. The activity was primarily found in membrane-enriched fractions rather than high-speed supernatant. NTE was solubilized from a mixture of mitochondrial and microsomal membranes with Triton X-100. The crude and solubilized activities had inhibitor char...
Recent findings of an association between anesthesia administration in the first three years of life and later learning disabilities have created concerns that anesthesia has neurotoxic effects on synaptogenesis, causing later learning problems. An alternative hypothesis is that those children who are likely to undergo surgery early in life have significant medical problems that are associated ...
Acute lithium intoxication is well known. A case of long tasting lithium neurotoxicity in an adolescent male is reported, who showed signs of cerebellar as well as brain stem involvement. Persistent lithium neurotoxicity is discussed and the recommendation made that this condition be considered irreversible only if no substantial recovery occurs in the first six months.
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