نتایج جستجو برای: neomorphic phases
تعداد نتایج: 109108 فیلتر نتایج به سال:
The vomeronasal organ (VNO) plays an important role in mediating semiochemical communications and social behaviors in terrestrial species. Genetic knockout of individual components in the signaling pathways has been used to probe vomeronasal functions, and has provided much insights into how the VNO orchestrates innate behaviors. However, all data do not agree. In particular, knocking out Trpc2...
IDH are family of enzymes that comprises three proteins, IDH1, IDH2 and IDH3. IDH1 is located in the cytoplasm while IDH2 and IDH3 are located in the mitochondria [1,2]. The IDHs are tricycle carboxylic acid cycle enzymes which convert isocitrate to α-KG via oxidative decarboxylation, producing NADPH (IDH1 and 2) and NADH (IDH3) [3]. IDH proteins are involved in diverse cellular processes inclu...
Pleuropulmonary blastoma (PPB) is the most frequent pediatric lung tumor and often the first indication of a pleiotropic cancer predisposition, DICER1 syndrome, comprising a range of other individually rare, benign and malignant tumors of childhood and early adulthood. The genetics of -associated DICER1 tumorigenesis are unusual in that tumors typically bear neomorphic missense mutations at on...
in recent years there has been considerable interest in the synthesis and separation of enantiomers of organic compounds especially because of their importance in the biochemistry and pharmaceutical industry. high-performance liquid chromatography is a very useful method for the direct separation of enantiomers. however, about 30−40 years ago, commercially available chiral stationary phases wer...
مطالعات اخیر نشان داده است که آهن از طریق کاتالیز واکنش تولید رادیکال آزاد هیدروکسیل (oh) می تواند باعث آسیب یاخته های اندوتلیال عروق کرونر و اکسیداسیون ldl شود و همچنین در آسیب میوکارد در مراحل ایسکمی و جریان دوباره خون به بافت قلبی نقش مهمی ایفا نماید. این مطالعه بطور تصادفی بر روی 130 بیمار مبتلا به انفارکتوس میوکارد (mi) شامل 94 مرد و 36 زن در بخش ccu بیمارستان قلب شهید رجائی تهران در دو مر...
Trans-lesion synthesis (TLS) is an important DNA-damage tolerance mechanism that permits ongoing DNA synthesis in cells harbouring damaged genomes. The E3 ubiquitin ligase RAD18 activates TLS by promoting recruitment of Y-family DNA polymerases to sites of DNA-damage-induced replication fork stalling. Here we identify the cancer/testes antigen melanoma antigen-A4 (MAGE-A4) as a tumour cell-spec...
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