Previously we showed that Ani (anisodamine)/Neo (neostigmine) combination produced anti-shock effect via activating α7 nicotinic acetylcholine receptor (α7nAChR). In this study, we aim to investigate the therapeutic effect and underlying mechanisms of Ani/Neo combination in acute lethal crush syndrome (CS). In rat and rabbit CS models, Ani/Neo combination increased the 24 h survival rates, impr...

BACKGROUND In many species, sex is determined by a system involving X and Y chromosomes, the latter having lost much of their genetic activity. Sex chromosomes have evolved independently many times, and several different mechanisms responsible for the degeneration of the Y chromosome have been proposed. Here, we have taken advantage of the secondary sex chromosome pair in Drosophila miranda to ...

The nuclear-electronic orbital ~NEO! method for the calculation of mixed nuclear-electronic wave functions is presented. Both electronic and nuclear molecular orbitals are expressed as linear combinations of Gaussian basis functions. In the NEO-HF ~Hartree-Fock! method, the energy corresponding to the single-configurational mixed nuclear-electronic wave function is minimized with respect to the...

Peer-to-peer, multiplayer games require secure event ordering, bounded latency between any two players, and a real-time transport protocol that includes congestion control. In the past, research has focused on solving one of these three issues, but has yet to address all of them in conjunction. In this paper, we design the NEO protocol to provide all three of these features in a fully-distribut...

This text aims to question the current “post-Fordist” model, after defining the former Fordism, and showing some latter configurations of “post-Fordism” in Britain, France, Germany and Japan. The compilation of knowledge concerning the organization of work was developed, first of all, by F. W. Taylor, based on technical and scientific methods and on the division of work. Nowadays, many expressi...

Retroviral gene expression is inhibited in embryonal carcinoma (EC) cells. We have constructed a recombinant retroviral vector that is capable of expressing the neomycin-resistance (neo) gene in EC cells. The critical modification that permits expression of the neo gene is the insertion of a composite simian virus 40 early gene-herpes simplex virus type 1 thymidine kinase gene (SVtk) promoter 3...

NEO-201 is a novel humanized IgG1 monoclonal antibody that was derived from an immunogenic preparation of tumor-associated antigens from pooled allogeneic colon tumor tissue extracts. It was found to react against a variety of cultured human carcinoma cell lines and was highly reactive against the majority of tumor tissues from many different carcinomas, including colon, pancreatic, stomach, lu...

The study of asteroid families has provided tremendous insight into the forces that sculpted the main belt and continue to drive the collisional and dynamical evolution of asteroids. The identification of asteroid families within the NEO population could provide a similar boon to studies of their formation and interiors. In this study we examine the purported identification of NEO families by D...

To delineate segments of the genome of the human protozoan parasite Leishmania major necessary for replication and expression, we developed a vector (pR-NEO) which can be reproducibly introduced into L. major. This DNA was derived from a 30-kilobase extrachromosomal amplified DNA bearing the dihydrofolate reductase-thymidylate synthase gene, with the coding region for neomycin phosphotransferas...

We compared the Neo-Sensitabs tablet assay to both reference M27-A2 broth microdilution and M44-A disk diffusion methods for testing susceptibilities of 110 isolates of Candida spp. and Cryptococcus neoformans to amphotericin B, caspofungin, fluconazole, itraconazole, and voriconazole. Neo-Sensitabs assay inhibition zone diameters in millimeters on three agars (Mueller-Hinton agar supplemented ...