Data taken from 1221 patients attending the Zoster Clinic of Moorfields Eye Hospital over the past 15 years were used to characterise the clinical appearance and behaviour of zoster mucous plaque keratitis (MPK). The typical greyish branching plaques are usually accompanied by a limbitis, stromal keratitis, or decrease in corneal sensation and are commonly associated with cataract, raised intra...

Fungal pores feel the pull S teinberg et al. report that fungi use motor proteins to distribute their nuclear pores around the nuclear envelope. In animal cells, the nuclear lamina holds the nuclear pores in place, ensuring that they are evenly spaced. The lamina prevents nuclear pores from clustering, promoting import of cargoes through the pores and helping to organize the chromosomes, which ...

Using cell culture models, we have investigated the relative importance of cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CaCC) in Cl secretion by mucous and serous cells of human airway glands. In transepithelial recordings in Ussing chambers, the CFTR inhibitor CFTR(inh)-172 abolished 60% of baseline Cl secretion in serous cells and 70% in ...

the normal and lateral line cycloid scales of the native species garra rossica (nikol’skii, 1900), one of the most common and poorly known cyprinid fish in south-eastern iran have been subjected to the scanning electron microscopy technique in order to study their detailed structure. normal scale below the dorsal fin showed a clearcut demonstration between the anterior and posterior region with...

Digital mucous cysts are common tumours of the distal interphalangeal joint, causing pain, cosmetic disfigurement and nail deformities. This study describes six patients suffering from digital mucous cysts, some of which recurred after surgery. Carbon dioxide laser vaporization was performed under local anaesthesia, resulting in complete remission in four out of six patients. In two patients, t...

Four patients with diabetes mellitus and no underlying clinical pulmonary disease were found to have extensive unilateral mucous occlusion of a major central bronchus. None of the patients had significant auscultatory findings suggestive of pulmonary secretions, and chest roentgenographic films were normal. Arterial blood gas evaluation failed to reveal the usual hypocapnia during ketoacidosis,...

Human bronchial epithelium has been maintained in organ culture in serum-supplemented medium for 4 months. After 4 to 6 weeks in culture, various changes in morphology were apparent. There was an increase in autophagic vacuoles in mucous, ciliated, and basal cells, a reduction in the height of the columnar cells, a decrease in the number of goblet mucous cells, and an increase in cells with sma...

Cystic fibrosis (CF) is caused by defects in the CFTR, a cAMP-activated Cl- channel of epithelia. The resulting reduction in epithelial fluid transport creates abnormally viscous secretions from airway mucous glands that may be a major factor in CF pathology. Mouse airways have few mucous glands, and the mouse model of CF exhibits no significant airway disease. Pigs and ferrets, however, have a...

The electron density resolution is 1000 times higher for synchrotron-radiation phase-contrast CT imaging than conventional X-ray absorption imaging in light elements, with which high-resolution X-ray imaging of biological soft tissue can be achieved. In the present study, we used phase-contrast X-ray CT to investigate human resected esophagus and esophageal carcinoma specimens. This technology ...

Bronchograms were made in eight men, chosen on clinical grounds as representative of three grades of severity in a series of 67 male bronchitis studied prospectively over a period of 10 years, with the object of ascertaining the anatomical condition at the end of this period. In the stationary group the bronchograms showed only a mild mucous reaction, and peripheral filling was generally good. ...