Adult naked mole-rats show a number of systemic adaptations to a crowded underground habitat that is low in oxygen and high in carbon dioxide. Remarkably, brain slice tissue from adult naked mole-rats also is extremely tolerant to oxygen deprivation as indicated by maintenance of synaptic transmission under hypoxic conditions as well as by a delayed neuronal depolarization during anoxia. These ...

Chloroperoxidase catalyzes the dismutation of chlorite-forming chloride, chlorine dioxide, chlorate, and oxygen as products. The yields of chlorine dioxide are variable because chloroperoxidase also catalyzes the decomposition of this compound and, in addition, moderate concentrations of chlorine dioxide inactivate the enzyme. Chloride, chlorate, and oxygen are the products of the decomposition...

Novel hantaviruses, recently detected in moles (order Eulipotyphla, family Talpidae) from Europe, Asia, and North America would predict a broader host range and wider ecological diversity. Employing RT-PCR, archival frozen tissues from the Chinese shrew mole (Uropsilus soricipes), broad-footed mole (Scapanus latimanus), coast mole (Scapanus orarius), Townsend's mole (Scapanus townsendii), and l...

The naked mole-rat (Heterocephalus glaber) is a long-lived, cancer resistant rodent and there is a great interest in identifying the adaptations responsible for these and other of its unique traits. We employed RNA sequencing to compare liver gene expression profiles between naked mole-rats and wild-derived mice. Our results indicate that genes associated with oxidoreduction and mitochondria we...

The ability of water-insoluble molecules such as triacylglycerols to partition from oil phases into phospholipid interfaces may be crucial to their hydrolysis by lipases in the aqueous environment of plasma and cells. This study uses high resolution and magic angle spinning 13C NMR spectros-copy to measure the solubility of the 8-carbon medium chain triacylglycerol, trioctanoin, in the lamellar...

The mass spectromctnc study of the vaporization of the compounds GeO (hex) and GeO(am) and of the mixture GeO (hex) + Ge(c) made it *Z possible to establish their mode of vaporization: Ge02(hex) GeO(g) + 1/20 (I) n GeO(am) (GeO) (g) (n 1. 2. 3) (II) n n/2 GeOJhex) + n/2 Ge(c) (GeO) (g) (n = 1,2,3) (III) c. n The enthalpies of vaporization are AH° (I) 121. 2± 1.6 kcal/mole AH» (II, n=l) = 53.4 ±...

A large mole vole from the early Middle Pleistocene of Armenia shows morphological features and hyposodonty intermediate between basal Early Pleistocene E. tarchancutensis and the late Middle Pleistocene to Recent southern mole vole E. lutescens. The occlusal morphology of the first lower molar is similar to Early Pleistocene forms but hypsodonty values do not overlap either with Early Pleistoc...

Consumption of high-fat diet (HFD) induces nonalcoholic fatty liver disease (NAFLD) and may lead to multiple complications affecting human health. In the present study, effect of Moringa oleifera leaf extract (MoLE) in alleviating HFD induced liver injury in mice has been reported. Liver histology and serum activity of hepatic marker enzymes i.e. aspartate aminotransferase (AST), alanine aminot...

The mechanism of signal transduction during magnetic compass orientation is rarely evident in vertebrates and is as yet unknown in mammals. This transmission has been associated with magnetite-based receptors innervated by the ophthalmic nerve or with the involvement of the eye, particularly the retina. We provide the first behavioural support for the cornea carrying the respective primary sens...

The incidence of mole pregnancy appears to be higher in Iran than in Europe or North America. This gave us an opportunity to study a number of biochemical measurements related to the thyroid. In 14 patients with hydatiform mole, the T3 resin uptake, serum thyroxine (T4), ETR, T3 RIA, human serum TSH (hTSH) and serum human Chorinic gonadotropin (hCG) were measured. Of the 14 patients 6 sho...