An unprecedented, 22-valence-electron triple-decker sandwich complex [(Cp*Mo)2{μ-η(6):η(6)-B4H4Ru2(CO)6}], 2, has been prepared. In an effort to generate analogous triple-deckers with group 6 metal carbonyl fragments in the middle deck, we have isolated [(Cp*MoCO)2(μ-H)2B4H4], 3, that provides the first direct evidence for the missing link between [(Cp*MoCl)2B3H7] and [(Cp*Mo)2B5H9] clusters.

The DMSO reductase family consists of proteins that catalyze oxygen atom transfer reactions. These proteins are characterized by a mononuclear Mo center that is ligated by one or two molybdopterin cofactors (through the two thiolates). DMSO reductase itself is ligated by two molybdopterin cofactors and catalyzes the reduction of dimethyl sulfoxide to dimethyl sulfide. This reaction is important...

Gephyrin is a multifunctional protein contributing to molybdenum cofactor (Moco) synthesis and postsynaptic clustering of glycine and GABA(A) receptors. It contains three major functional domains (G-C-E) and forms cytosolic aggregates and postsynaptic clusters by unknown mechanisms. Here, structural determinants of gephyrin aggregation and clustering were investigated by neuronal transfection o...

Background Delayed myocardial enhancement (DE) sequences have become essential in cardiac MRI (CMRI) for visualization of abnormal myocardium. DE sequences require an inversion pulse to null normal myocardium, and the introduction of phase-sensitive inversion recovery (PSIR) sequences, which are less sensitive to small variations in inversion time (TI), have provided a suitable alternative to m...

Developing software that can be modified and evolved easily is a challenging task. Yet, the fastpaced market requires quick adaptation of products in reaction to emerging requirements. As a basis for flexible software, we proposed to develop software based on Model-Integrating Components (MoCos) in previous work [1]. A MoCo is a non-redundant, reusable and executable combination of logically re...

A 27,690-bp gene cluster involved in the degradation of the plant alkaloid nicotine was characterized from the plasmid pAO1 of Arthrobacter nicotinovorans. The genes of the heterotrimeric, molybdopterin cofactor (MoCo)-, flavin adenine dinucleotide (FAD)-, and [Fe-S] cluster-dependent 6-hydroxypseudooxynicotine (ketone) dehydrogenase (KDH) were identified within this cluster. The gene of the la...

BACKGROUND Neurological abnormalities including a variety of subtle deficits such as discrete impairments in sensory integration, motor coordination (MOCO), and sequencing of complex motor acts are frequently found in patients with schizophrenia (SZ) and commonly referred to as neurological soft signs (NSS). Asperger-syndrome (AS) is characterized by sensory-motor difficulties as well. However,...

GDC-0834, a Bruton’s tyrosine kinase inhibitor investigated as a potential treatment of rheumatoid arthritis, was previously reported to be extensively metabolized by amide hydrolysis such that no measurable levels of this compound were detected in human circulation after oral administration. In vitro studies in human liver cytosol determined that GDC-0834 (R)-N-(3-(6-(4-(1,4-dimethyl-3-oxopipe...

We study output-sensitive algorithms and complexity for multiobjective combinatorial optimization problems. In this computational complexity framework, an algorithm for a general enumeration problem is regarded efficient if it is output-sensitive, i.e., its running time is bounded by a polynomial in the input and the output size. We provide both practical examples of MOCO problems for which suc...

Synthesizing novel views of dynamic humans from stationary monocular cameras is a specialized but desirable setup. This particularly attractive as it does not require static scenes, controlled environments, or capture hardware. In contrast to techniques that exploit multi-view observations, the problem modeling scene single view significantly more under-constrained and ill-posed. this paper, we...