نتایج جستجو برای: mir 103a 3p

تعداد نتایج: 49246  

Journal: :Biocell 2023

Background: LncRNA DLX6-AS1 has been uncovered to exert effects on various cancers. Nevertheless, the impacts of endometrial cancer (EC) development remained obscure. The study explored influence EC progression via microRNA (miR)-374a-3p/zinc-finger protein (ZFX) axis.Methods: cell lines were collected and DLX6-AS1, miR-374a-3p, ZFX levels in detected. cells transfected with constructs examine ...

Journal: :Molecular and Cellular Neuroscience 2016
Amrit S. Boese Reuben Saba Kristyn Campbell Anna Majer Sarah Medina Lynn Burton Timothy F. Booth Patrick Chong Garrett Westmacott Sucharita M. Dutta Julian A. Saba Stephanie A. Booth

Discrepancy in synaptic structural plasticity is one of the earliest manifestations of the neurodegenerative state. In prion diseases, a reduction in synapses and dendritic spine densities is observed during preclinical disease in neurons of the cortex and hippocampus. The underlying molecular mechanisms of these alterations have not been identified but microRNAs (miRNAs), many of which are enr...

2017
Hirofumi Yoshino Masaya Yonemori Kazutaka Miyamoto Syuichi Tatarano Satoshi Kofuji Nijiro Nohata Masayuki Nakagawa Hideki Enokida

Previous studies showed that five miRNAs (miR-885-5p, miR-1274, miR-210-3p, miR-224 and miR-1290) were upregulated the most in clear cell renal cell carcinoma (ccRCC). Our focus was to understand from a clinical standpoint the functional consequences of upregulating miR-210-3p. Towards this, we utilized the CRISPR/Cas9 gene editing system to deplete miR-210-3p in RCC cell lines (786-o, A498 and...

2015
Giovanni Lugli Aaron M. Cohen David A. Bennett Raj C. Shah Christopher J. Fields Alvaro G. Hernandez Neil R. Smalheiser Baohong Zhang

To assess the value of exosomal miRNAs as biomarkers for Alzheimer disease (AD), the expression of microRNAs was measured in a plasma fraction enriched in exosomes by differential centrifugation, using Illumina deep sequencing. Samples from 35 persons with a clinical diagnosis of AD dementia were compared to 35 age and sex matched controls. Although these samples contained less than 0.1 microgr...

Journal: :International journal of molecular medicine 2016
Shifan Tan Huijuan Shi Mingchen Ba Shengqv Lin Hongsheng Tang Xiaoqi Zeng Xiangliang Zhang

The chemoresistance of colon cancer cells limits the efficacy of chemotherapy. miR-409-3p has been shown to be downregulated in various types of cancer. In the present study, we examined the role of miR-409-3p in colon cancer as well as the effects of miR‑409-3p on the sensitivity of colon cancer cells to oxaliplatin. The expression of miR-409 was significantly downregulated in the human colon ...

2017
Tao Wang Jingjing Hou Zengpeng Li Zihan Zheng Jie Wei Dan Song Tao Hu Qiao Wu James Y. Yang Jian-chun Cai

MicroRNAs are a novel class of gene regulators that function as oncogenes or tumor suppressors. In our current study, we investigated the role of miR-15a-3p and miR-16-1-3p in the regulation of Twist1 expression and EMT process. Our bioinformatics analysis suggested that on the 3' UTR of Twist1, there are two conserved miRNA recognition sites for miR-15a-3p and miR-16-1-3p respectively. Interes...

Journal: :European review for medical and pharmacological sciences 2017
Z-X Cheng Y-X Song Z-Y Wang Y Wang Y Dong

OBJECTIVE Previous research indicated that miR-144-3p was associated with the regulation of the carcinogenic processes, but the role of miR-144-3p in glioblastoma (GBM) remains unclear. In this study, we aimed to analyze the role of miR-144-3p in GBM. PATIENTS AND METHODS The expression of miR-144-3p was measured in GBM tissues and adjacent non-malignant tissues using qRT-PCR. The correlation...

2014
Rita Lh Yim Kwan Yeung Wong Yok Lam Kwong Florence Loong Chung Ying Leung Raymond Chu William Wai Lung Lam Pak Kwan Hui Raymond Lai Chor Sang Chim

Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin's lymphoma (NHL). In cancers, tumor suppressive microRNAs may be silenced by DNA hypermethylation. By microRNA profiling of representative EBV-negative MCL cell lines before and after demethylation treatment, miR-155-3p was found significantly restored. Methylation-specific PCR, verified by pyrosequencing, showed complete methylatio...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2012
Joseph A Jude Mythili Dileepan Subbaya Subramanian Julian Solway Reynold A Panettieri Timothy F Walseth Mathur S Kannan

CD38, a membrane protein expressed in airway smooth muscle (ASM) cells, plays a role in cellular Ca(2+) dynamics and ASM contractility. In human ASM (HASM) cells, TNF-α induces CD38 expression through activation of MAPKs, NF-κB, and AP-1, and its expression is differentially elevated in cells from asthmatic patients compared with cells from nonasthmatic subjects. The CD38 3'-untranslated region...

2017
Shanqi Guo Peiying Yang Xingkang Jiang Xiaojiang Li Yuanyuan Wang Xin Zhang Binxu Sun Yao Zhang Yingjie Jia

Although previous studies suggested that microRNA-506-3p (miR-506-3p) was frequently downregulated, and functioned as a tumor suppressor in several cancers, the biological role and intrinsic regulatory mechanisms of miR-506-3p in non-small cell lung cancer (NSCLC) remain elusive. The present study found miR-506-3p expression was downregulated in advanced NSCLC tissues and cell lines. The expres...

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