The inhibition of crystallization of amorphous acetaminophen (ACTA) by polyvinylpyrrolidone (PVP) and polyacrylic acid (PAA) was studied using amorphous solid dispersions prepared by melt quenching. Co-melting with PVP and PAA decreased the average molecular mobility, as indicated by increases in glass transition temperature and enthalpy relaxation time. The ACTA/PAA dispersion exhibited much s...

Composites of ethyleneevinyl acetate copolymer with two different layered double hydroxides have been obtained by melt blending and these have been characterized by X-ray diffraction, transmission electron microscopy, thermogravimetric analysis, thermogravimetric analysis connected to mass spectroscopy and cone calorimetry. There is some small difference in dispersion between the zinc-containin...

Primary boron containing dispersoids grown from the melt in a Ti-45.5at.%Al-1.6at.%Fel.lat.%V-0.7at.%B alloy, and then annealed at 1473K, have been investigated using optical microscopy, conventional transmission electron microscopy (CTEM) and analytical electron microscopy. The dispersoid morphology is in the form of high aspect ratio plates, hundreds of microns across and cross-sectional widt...

In order to improve the aqueous solubility and dissolution of Tacrolimus (TAC), amorphous solid dispersions of TAC were prepared by hot melt extrusion with three hydrophilic polymers, Polyvinylpyrrolidone vinyl acetate (PVP VA64), Soluplus® and Hydroxypropyl Cellulose (HPC), at a drug loading of 10% w/w. Molecular modeling was used to determine the miscibility of the drug with the carrier polym...

CONTEXT Solubility limitation of BCS class II drugs pose challenges to in vitro release. OBJECTIVE To investigate the miscibility of Aprepitant (APR) and Soluplus(®) (SOL) for hot melt extrusion (HME) viability and improved in vitro release of APR. METHODS Solubility parameters of APR and SOL from group contribution methods were evaluated. Heat-cool-heat differential scanning calorimetry (D...

We carried out viscosity measurements and sampling of a crystal suspension derived from alkali olivine basalt from the Matsuura district, SW Japan, at subliquidus temperatures from 1230 °C to 1140 °C under 1 atm with NNO oxygen buffered conditions. Viscosity increased from 31 to 1235 Pa s with a decrease in temperature from 1230 to 1140 °C. On cooling, olivine first appeared at 1210 °C, followe...

In this work, we study the influence of polymer chain length (m), based on Lennard-Jones potential, and nanoparticle (NP)-polymer interaction strength (ɛnp) on aggregation and dispersion of soft repulsive spherically structured NPs in polymer melt using coarse-grain molecular dynamics simulations. A phase diagram is proposed where transitions between different structures in the NP-polymer syste...

Volumetrically significant melt production requires crustal temperatures above approximately 800 °C. At the grain scale, the former presence of melt may be inferred based on various microstructures, particularly pseudomorphs of melt pores and grain-boundary melt films. In residual migmatites and granulites, evidence of melt-extraction pathways at outcrop scale is recorded by crystallized produc...