Selecting efficiently a minimum amount of text from a largescale text corpus to achieve a maximum coverage of certain units is an important problem in spoken language processing area. In this paper, the above text selection problem is first formulated as a maximum coverage problem with a Knapsack constraint (MCK). An efficient rank-predicted pseudo-greedy approach is then proposed to solve this...

N. Saha, R. Surdeanu, M. Marchevsky, G. J. Nieuwenhuys, C. D. Dewhurst, R. J. Wijngaarden, D. McK. Paul, and P. H. Kes Kamerlingh Onnes Laboratory, Leiden University, POB 9504 Leiden, The Netherlands Division of Physics and Astronomy, Vrije Universiteit, De Boelelaan 1081, 1081HV Amsterdam, The Netherlands NEC Research Institute, 4 Independence Way, Princeton, New Jersey 08540 Institut Laue-Lan...

We consider a version of the knapsack problem in which an item size is random and revealedonly when the decision maker attempts to insert it. After every successful insertion the decisionmaker can dynamically choose the next item based on the remaining capacity and available items,while an unsuccessful insertion terminates the process. We build on a semi-infinite relaxationi...

Glycogen storage disease type II (Pompe disease; MIM 232300) stems from the deficiency of acid alpha-glucosidase (GAA; acid maltase; EC 3.2.1.20), which primarily involves cardiac and skeletal muscles. An adeno-associated virus 2/8 (AAV2/8) vector containing the muscle creatine kinase (MCK) (CK1) reduced glycogen content by approximately 50% in the heart and quadriceps in GAA-knockout (GAA-KO) ...

Electrocytes, the current-producing cells of electric organs (EOs) in electric fish, are unique in that they derive from striated muscle and they possess biochemical characteristics of both muscle and non-muscle cells. In the freshwater teleost Sternopygus macrurus, electrocytes are multinucleated cells that do not contract yet retain expression of some proteins common to skeletal muscle cells....

In order to extract any ULF signature associated with earthquakes, the principal component analysis (PCA) and singular spectral analysis (SSA) have been performed to investigate the possibility of discrimination of signals from different sources (geomagnetic variation, artificial noise, and the other sources (earthquake-related ULF emissions)). We adopt PCA to the time series data observed at c...

BACKGROUND Congestive heart failure (CHF) is a leading cause of morbidity and mortality, and oxidative stress has been implicated in the pathogenesis of cachexia (muscle wasting) and the hallmark symptom, exercise intolerance. We have previously shown that a nitric oxide-dependent antioxidant defense renders oxidative skeletal muscle resistant to catabolic wasting. Here, we aimed to identify an...

This paper presents the algorithms and results of our participation to the medical image annotation task of ImageCLEFmed 2007. We proposed, as a general strategy, a multi-cue approach where images are represented both by global and local descriptors, so to capture different types of information. These cues are combined during the classification step following two alternative SVM-based strategie...

To investigate the requirement for pRb in myogenic differentiation, a floxed Rb allele was deleted either in proliferating myoblasts or after differentiation. Myf5-Cre mice, lacking pRb in myoblasts, died immediately at birth and exhibited high numbers of apoptotic nuclei and an almost complete absence of myofibers. In contrast, MCK-Cre mice, lacking pRb in differentiated fibers, were viable an...

Clustered guanine residues in DNA readily generate hairpin or a variety of tetrahelical structures. The myogenic determination protein MyoD was reported to bind to a tetrahelical structure of guanine-rich enhancer sequence of muscle creatine kinase (MCK) more tightly than to its target E-box motif [K. Walsh and A. Gualberto (1992) J. Biol. Chem., 267, 13714-13718], suggesting that tetraplex str...