Identification of novel drug targets and chemotherapeutic agents is a high priority in the fight against cancer. Here, we report that MAD-28, a designed cluvenone (CLV) derivative, binds to and destabilizes two members of a unique class of mitochondrial and endoplasmic reticulum (ER) 2Fe-2S proteins, mitoNEET (mNT) and nutrient-deprivation autophagy factor-1 (NAF-1), recently implicated in canc...

OBJECTIVE To investigate effects of mandibular advancement device (MAD) therapy for obstructive sleep apnoea hypopnea syndrome (OSAHS) on the genioglossus contractile properties and fibre-type distribution. MATERIALS AND METHODS Thirty 6-month old male New Zealand white rabbits were randomised into three groups: OSAHS, MAD, and controls. Rabbits in Group OSAHS and Group MAD were established a...

Let mad(G) denote the maximum average degree (over all subgraphs) of G and let χi(G) denote the injective chromatic number of G. We prove that if mad(G) ≤ 5 2 , then χi(G) ≤ ∆(G) + 1; and if mad(G) < 42 19 , then χi(G) = ∆(G). Suppose that G is a planar graph with girth g(G) and ∆(G) ≥ 4. We prove that if g(G) ≥ 9, then χi(G) ≤ ∆(G) + 1; similarly, if g(G) ≥ 13, then χi(G) = ∆(G).

As I was reflecting deeply in front of the statue of Bodhisattva of Gr~ and Wisdom in the University Muset~n, I was startled to see Jane. Having heard from Don that he had asked the old cats to reflect on the 20 years of ACL, Jane had decided that she should drop in on some of them to seek their advice concerning the future of ACL. I wish to thank Alice, the Cheshire Puss, and Lewis Carroll for...