Chromatins prepared from leukemic lymphosarcoma cell(s), (LS), acute lymphoblastic leukemia cells, chronic lymphocytic leukemia cells and normal tissue culture lymphocytes (NC-37) were studied with respect to their chemical compositions, thermal denaturation profiles, and template activities. Acute lymphoblastic leukemia and LS chromatins had approximately 2 to 4 times the nonhistone protein an...

fms-like tyrosine kinase-3 is a receptor tyrosine kinase expressed by immature hematopoietic cells and is important for the normal development of stem cells and the immune system. mutations of fms-like tyrosine kinase-3 have been detected in about 30% of patients with acute myelogenous leukemia and a small number of patients with acute lymphoblastic leukemia. the fms-like tyrosine kinase-3 muta...

Donor-derived malignancies after allogeneic hematopoietic stem cell transplantation and after solid organ transplantation are considered as rare diseases. We have prospectively searched for donor cell leukemia in a 12-year period, in a single institution, in a group of 106 consecutive patients allografted because of leukemia. We have identified seven cases of donor cell leukemia; six were allog...

ubiquitin - proteasome system (ups), the major protein degradation pathway in the cells, typically degrades short - lived and damaged proteins and regulates growth and stress responses. this pathway is altered in various cancers, including acute lymphoblastic leukemia (all). all begins with a change in bone marrow cells and is the most common type of leukemia in children under 15 years. ube2q1 ...

introduction:  acute lymphoblastic leukemia (all) is the most common malignancy in children and the main form of childhood leukemia (75%). all different treatment options have a great impact on children weight and appetite. the improving prognosis for children with cancer refocuses attention to long-term outcomes with an emphasis on quality of life. more survival rate allows researchers to eval...

background evidence indicates rfc1 g80a polymorphism as a risk factor for a number of cancers. increasing studies have been conducted on the association of rfc1 g80a polymorphism with acute lymphoblastic leukemia (all) risk. however, the results were  controversial. the aim of the present study was to derive a more precise estimation of the relationship.  materials and method pubmed, embase, we...

Introduction: L-asparaginase and corticosteroids are widely used in the chemotherapy of acute lymphoblastic leukemia (ALL). This combination is known to cause several adverse effects one which hypertriglyceridemia. Although condition asymptomatic reversible it can lead serious complications.

Detection of CD10, CD34 and their combined expression on Childhood Acute Lymphoblastic Leukemia and the association with clinical outcome in Indonesia 85 Detection of CD10, CD34 and their combined expression on Childhood Acute Lymphoblastic Leukemia and the association with clinical outcome in Indonesia CD10 and CD34 are surface markers that have been reported to have prognostic relevance in ch...

background: acute lymphoblastic leukemia is a lymphoid malignancy, resulting from autonomous proliferation of monoclonal abnormal stem cell. the aim of this study was to evaluate the response rate and prognostic factor of adult patients suffering from acute lymphoblastic leukemia, who were treated with chemotherapy in south east of iran and demographic methods were used for this study.   method...