In the present study, the authors measured vascular functioning of the forearm of 25 male subjects via ultrasound (Doppler imaging) at time zero and after 4 hours after consuming a high-fat meal. Using a single-blinded crossover design, the subjects either consumed a placebo oil (no DHA/EPA present) or fish oil (providing a total amount of DHA/EPA amounting to 5.4 grams-3.24 grams DHA plus 2.16...

Abstract Marine microalgae have received much attention as a sustainable source of the two health beneficial omega-3-fatty acids docosahexaenoic acid (DHA, C22:6) and eicosapentaenoic (EPA, C20:5). However, photoautotrophic monocultures can only produce either DHA or EPA enriched biomass. An alternative may be co-cultivation Tisochrysis lutea DHA-producer with Microchloropsis salina for simulta...

Embryonic mortality in cattle may occur because of inadequate inhibition of uterine secretion of prostaglandin (PG) F2a mediated by bovine interferon-t (bIFN-t). The objectives of the present study were to determine whether polyunsaturated fatty acids inhibit secretion of PGF2a from bovine endometrial cells induced by stimulating protein kinase C with phorbol 12,13 dibutyrate (PDBu) and to inve...

The marine diatom Phaeodactylum tricornutum can accumulate up to 30% of the omega-3 long chain polyunsaturated fatty acid (LC-PUFA) eicosapentaenoic acid (EPA) and, as such, is considered a good source for the industrial production of EPA. However, P. tricornutum does not naturally accumulate significant levels of the more valuable omega-3 LC-PUFA docosahexaenoic acid (DHA). Previously, we have...

To determine the mechanism by which the (n-3) fatty acids (FA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) decrease proliferation and induce apoptosis in MDA-MB-231 human breast cancer cells, we examined the effects of EPA and DHA on the lipid composition of lipid rafts as well as epidermal growth factor receptor (EGFR) raft localization and phosphorylation. (n-3) FA (a combinati...

BACKGROUND Food supplemented with fish oil improves clinical signs and weight bearing in dogs with osteoarthritis (OA). OBJECTIVE Determine whether increasing the amount of fish oil in food provides additional symptomatic improvements in OA. ANIMALS One hundred and seventy-seven client-owned dogs with stable chronic OA of the hip or stifle. METHODS Prospective, randomized clinical trial u...

OBJECTIVES Previous randomized controlled trials (RCTs) suggest that depression can be effectively treated by omega-3 polyunsaturated fatty acids (PUFAs). Therefore, we conducted this meta-analysis to systematically evaluate the clinical applicability of the combination of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), which are the two major bioactive types of PUFAs, in depressed ...

polyunsaturated fatty acids (pufas) particularly ω-3 pufas showed great assure in prevention of cardiovascular diseases (cvd). the evidence for cv benefits of pufa comes from eicosapentaenoic acid (epa) with or without docosahexaenoic acid (dha) in primary prevention, after myocardial infarction (mi), with heart failure (hf). the epidemiologic studies and trials showing the benefits of pufa, sp...

BACKGROUND Dietary intake of ω3 polyunsaturated fatty acids (ω3-PUFAs) reduces progression of atherosclerosis and prevents future cardiovascular events. Macrophages are key players in the pathogenesis of aortic aneurysm. The effects of ω3-PUFAs on abdominal aortic aneurysm (AAA) formation and macrophage-mediated inflammation remain unclear. METHODS AND RESULTS: The AAA model was developed by an...

BACKGROUND Omega-3 fatty acids (FAs) appear to reduce the risk of sudden death from myocardial infarction. This reduction is believed to occur via the incorporation of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into the myocardium itself, altering the dynamics of sodium and calcium channel function. The extent of incorporation has not been determined in humans. METHODS AND RES...