paraneoplastic neurological syndromes have only been described with pleural mesothelioma in five cases. we have described a 72-year-old man who developed anterograde amnesia 27 months after diagnosis of epithelioid pleural mesothelioma. investigations revealed a limbic encephalitis with no alternative causes identified. limbic encephalitis is a classical paraneoplastic syndrome and presentation...

The concept of a (single) limbic system is shown to be outmoded. Instead, anatomical, neurophysiological, functional neuroimaging, and neuropsychological evidence is described that anterior limbic and related structures including the orbitofrontal cortex and amygdala are involved in emotion, reward valuation, and reward-related decision-making (but not memory), with the value representations tr...

A baby is dependent on its primary caregiver (hereafter referred to as 'mother') for its emotional regulation. The development of emotional self-regulation is dependent on the growth and myelinisation of connections between cortical (control) and limbic (emotion) structures in the infant brain. The subcortical sympathetic limbic system is dominant from birth, and it is only at 14-18 months of a...

Affective temperaments are considered to be antecedents or sub-syndromal manifestations of bipolar disorders. It is, however, unknown how these temperaments develop into bipolar disorders. We hypothesize that: [1] just before the onset of bipolar disorder, the left medial frontal gyrus (MFG) of cyclothymic and/or hyperthymic healthy subjects may degenerate and shrink in volume concomitantly wit...

The pathogenesis of major depression (MD) remains unclear despite intensive research in the last decades which brought up a multitude of findings illustrating the complexity of this disorder. In this paper we will summarize the evidence pointing towards a structural alteration of the basal limbic system in MD and depression in Parkinson's disease (PD). Transcranial ultrasound and MRI studies in...

Glucocorticoids are expressed in the central nervous system. Radioligand binding studies have shown their presence in the neurons of the limbic system, a structure involved in mood control and subtle regulation of hypothalamic-pituitary-adrenal (HPA) axis. Structures of the limbic system are also rich in dopaminergic innervation. It has been hypothesized that glucocorticoids may be important in...