background: more than 250,000 people die annually of pancreatic cancer, worldwide. the highest incidence and mortality rates of pancreatic cancer are reported in developed countries. in developing countries the rate have been stabilizing over the past two decades but in countries which rates have been low for decades is now increasing. recognizing pancreatic cancer's risk factors and its preven...

background: as condition and component of culture determine fate map of spermatogonial stem cells (sscs), the aim of this study was to evaluate of growth factors gdnf, lif and ra on proliferation and differentiation of ssc. materials and methods: sscs were cultured in two groups: the first group gdnf and lif and the second group ra. the number of clumps and colony formation was monitored during...

background: the anticancer agent imatinib (im) is a small molecular analog ofatp that inhibits tyrosine kinase activity of platelet derived growth factors (pdgfs)and stem cell factor (scf) receptor in cancer cells. however these factors have a keyrole in regulating growth and development of normal sertoli, leydig and germcells.objective: the aim of this study was to determine cell viability, pd...

this paper is to develop a knowledge management (km) model in some iranian academic research centers (arc) based on km critical success factors. general km critical success factors (csf) were identified through literature review. then the research procedure led to the identification of km critical success factors in iranian arcs including 16 different factors. it was done through first stage su...

the molecular basis of metastatic potential of human breast carcinoma cells can be useful information to determine the practical implications in the diagnosis, determining prognosis and treatment of breast cancer. the aim of this study was to identify predictors of aggressive biological behavior and metastatic potential in breast carcinoma among a number of intrinsic biomarkers of tumor cells. ...

involvement of genetic alterations in breast cancer, one of the most common types of female malignancie, has been well documented . among the possible alterations, mutations in several genes including p53 as an important prognostic factor, have been extensively studied. mutated p5 protein has longer half-life than the wild type protein that is detectable by immunohistochemistry (ihc). our study...

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