Europium and terbium complexes of two structurally related ligands have been evaluated as optical probes to monitor changes in lysosomal pH; calibration using ionophores and fluorescent probes allows monitoring of the time dependence of lysosomal pH change, examining the green/red intensity ratio from internalised Tb-Eu complexes.

Helical peptide foldamers rich in α-aminoisobutyric acid (Aib) act as peptaibol-mimicking ionophores in the phospholipid bilayers of artificial vesicles. Racemic samples of these foldamers are more active than their enantiopure counterparts, which was attributed to differing propensities to form aggregates with crystal-like features in the bilayer.

Simian virus 40 small-t antigen allows the growth of CV-1 cells in concentrations of theophylline that normally prevent cell cycling. This effect is completely overcome by two ionophores that uncouple mitochondria and by the anti-mitochondrial drug methylglyoxal bis-(guanylhydrazone).

A gene which was shown to be cotranscribed with the NAD+-dependent malic enzyme gene (maeE) of Streptococcus bovis ATCC 15352 was revealed to encode L-malate-specific permease (MaeP), which showed high activity at low pHs (pH 5.1 to 5.9). MaeP was strongly inhibited by the ionophores nigericin and valinomycin.

Abstract The decentralisation of accurate determination the ammonium ion (NH 4 + ) is relevant for environmental monitoring (i. e., nitrogen cycle) and certain clinical applications (e. g., kidney liver diseases). Potentiometric ionophore‐based sensors are one alternative these purposes in terms versatile implementation, though potassium (K known to be a major source interference. We herein inv...

This study examined the involvement of ATPase activity in the acid tolerance response (ATR) of Bacillus cereus ATCC14579 strain. In the current work, B. cereus cells were grown in anaerobic chemostat culture at external pH (pHe ) 7.0 or 5.5 and at a growth rate of 0.2 h-1 . Population reduction and internal pH (pHi ) after acid shock at pH 4.0 was examined either with or without ATPase inhibito...