BACKGROUND Specific immunotherapy via the subcutaneous or oral route is associated with local and, in some cases, systemic side effects and suffers from low patient compliance. Due to its unique immunological features, the skin represents a promising target tissue for effective and painless treatment of type I allergy. The current study was performed to compare the efficacy of transcutaneous im...

The brains of mice infected with Japanese encephalitis (JE) virus by intracerebral inoculation (IC), intraperitoneal inoculation with sham intracerebral inoculation (IP+sIC), and intraperitoneal inoculation (IP) were studied by light and electron microscopy. The mortality rates and mean survival days were 100% and 4.8 days for the IC group, 92% and 9.0 days for the IP+sIC group, and 58% and 13....

the objective of this study was to evaluate several drug combinations for intraperitoneal anaesthesia in laboratory rats. following dose determination of anaesthetics in a pilot study, 45 healthy adult male rats were randomly assigned in 9 treatment groups and received propofol (alone or in combination with xylazine, midazolam, or ketamine) or ketamine (in combination with xylazine, midazolam, ...

Shock and resuscitation render patients more susceptible to acute lung injury due to an exacerbated immune response to subsequent inflammatory stimuli. To study the role of innate immunity in this situation, we investigated acute lung injury in an experimental model of ischemia-reperfusion (I-R) followed by an early challenge with live bacteria. Conscious rats (N = 8 in each group) were submitt...

Etoposide (ETP) is a topoisomerase Ⅱ (TOP Ⅱ) inhibitor and one of the leading chemotherapeutic drugs for treating wide variety tumors. However, ETP induced hepatotoxicity nephrotoxicity limits its clinical use. This study aims to investigate protective potential taurine (Tau) mitigated histopathological changes in liver kidneys female albino rats treated with ETP. A total 18 were divided into t...

Cancer-related sarcopenia is associated with impaired energy metabolism and increased oxidative stress production in skeletal muscles. With an aim to treat cancer-related using dietary intervention, we investigated the effects of vitamin B2 (VB2) E (VE), which are recognized have antioxidant effects, on CT26 mouse colon cancer cells muscles vitro vivo. VB2 suppressed tumor growth by suppressing...

INTRODUCTION Mechanical ventilation with even moderate-sized tidal volumes synergistically increases lung injury in sepsis and has been associated with proinflammatory low-molecular-weight hyaluronan production. High-molecular-weight hyaluronan (HMW HA), in contrast, has been found to be anti-inflammatory. We hypothesized that HMW HA would inhibit lung injury associated with sepsis and mechanic...

Abstract Background It is apparent that the interaction between platelets and eosinophils plays a critical role in activation of allergic inflammation. We investigated whether blocking glycoprotein (GP) IIb/IIIa receptor can attenuate inflammation airway hyperresponsiveness through inhibition platelet–eosinophil aggregation (PEA) asthma. Methods BALB/c mice were sensitized by intraperitoneal in...